5-Pyrimidinol, 4-methyl-, 3-oxide (9CI)

Base Information

• Chemical Name: 5-Pyrimidinol, 4-methyl-, 3-oxide (9CI)
• CAS No.: 116319-09-6
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.115
• Mol file: 116319-09-6.mol

Synonyms:5-Pyrimidinol, 4-methyl-, 3-oxide (9CI)

Chemical Property of 5-Pyrimidinol, 4-methyl-, 3-oxide (9CI)

Chemical Property:

• PSA: 58.58000
• LogP: 0.52410

Purity/Quality:

5-PYRIMIDINOL, 4-METHYL-, 3-OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinol, 4-methyl-, 3-oxide (9CI)

There total 6 articles about 5-Pyrimidinol, 4-methyl-, 3-oxide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

4-Methyl-5-hydroxypyrimidine (101257-87-8) → 4-Methyl-5-hydroxypyrimidine 1-Oxide (116319-08-5) + 4-Methyl-5-hydroxypyrimidine 3-Oxide (116319-09-6)

Guidance literature:

With 4-nitroperbenzoic acid; In ethanol;

DOI:10.1007/BF00482500

Reference yield:

6-Methyluracil (626-48-2) → 4-Methyl-5-hydroxypyrimidine 3-Oxide (116319-09-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 24 percent / potassium persulfate / aq. NaOH / Ambient temperature

2: 78 percent / 10percent H₂SO₄ / 0.17 h / 85 - 90 °C

3: 81 percent / 9 h

4: 84 percent / POCl₃/dimethylaniline / 2 h / Heating

5: 83 percent / KOH / Raney nickel / aq. ethanol / 2 h / Heating

6: 26 percent / p-nitroperbenzoic acid / ethanol

With 4-nitroperbenzoic acid; potassium hydroxide; potassium peroxomonosulphate; sulfuric acid; 2,3-Dimethylaniline; trichlorophosphate; nickel; In sodium hydroxide; ethanol;

DOI:10.1007/BF00482500

Reference yield:

5-Acetoxy-6-methyluracil (28918-95-8) → 4-Methyl-5-hydroxypyrimidine 3-Oxide (116319-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / POCl₃/dimethylaniline / 2 h / Heating

2: 83 percent / KOH / Raney nickel / aq. ethanol / 2 h / Heating

3: 26 percent / p-nitroperbenzoic acid / ethanol

With 4-nitroperbenzoic acid; potassium hydroxide; 2,3-Dimethylaniline; trichlorophosphate; nickel; In ethanol;

DOI:10.1007/BF00482500

upstream raw materials:

4-Methyl-5-hydroxypyrimidine

6-Methyluracil

5-Acetoxy-6-methyluracil

6-Methyluracil-5-sulfate

Refernces