2-amino-N-cyclopropylbenzamide

Base Information

• Chemical Name: 2-amino-N-cyclopropylbenzamide
• CAS No.: 30510-67-9
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.218
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50366128
• Nikkaji Number: J2.601.128K
• Wikidata: Q82151225
• Mol file: 30510-67-9.mol

Synonyms:2-amino-N-cyclopropylbenzamide;30510-67-9;Benzamide, 2-amino-N-cyclopropyl-;Benzamide,2-amino-N-cyclopropyl-;N-Cyclopropyl-2-aminobenzamide;SCHEMBL2060435;2-amino-N-cyclopropyl-benzamide;DTXSID50366128;HMS1755O01;2-amino-N~1~-cyclopropylbenzamide;BBL013210;MFCD03015446;STK795720;AKOS000264178;WAY-624917;AS-61431;BB 0218407;CS-0037154;FT-0683237;EN300-09734;W11447;A876163;J-508060;Z56987405

Chemical Property of 2-amino-N-cyclopropylbenzamide

Chemical Property:

• Vapor Pressure: 2.84E-06mmHg at 25°C
• Refractive Index: 1.61
• Boiling Point: 389.5 °C at 760 mmHg
• PKA: 14.43±0.20(Predicted)
• Flash Point: 189.4 °C
• PSA: 55.12000
• Density: 1.2 g/cm³
• LogP: 2.13310
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 201

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-N-cyclopropylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NC(=O)C2=CC=CC=C2N

Technology Process of 2-amino-N-cyclopropylbenzamide

There total 5 articles about 2-amino-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

isatoic anhydride (118-48-9) + Cyclopropylamine (765-30-0) → 2-amino-N-cyclopropylbenzamide (30510-67-9)

Guidance literature:

With triethylamine; In ethanol; at 30 - 70 ℃;

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) + Cyclopropylamine (765-30-0) → 2-amino-N-cyclopropylbenzamide (30510-67-9)

Guidance literature:

With iodine; In ethanol; Reflux;

DOI:10.1021/acs.joc.8b01218

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + Cyclopropylamine (765-30-0) → 2-amino-N-cyclopropylbenzamide (30510-67-9)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

anthranilic acid

Cyclopropylamine

isatoic anhydride

2-Aminobenzyl alcohol

Downstream raw materials:

2-{[(cyclopropyl)amino]methyl}aniline

3-cyclopropyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

2-(4-chloro-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)-N-cyclopropylbenzamide

N-cyclopropyl-2-((2,5-dichloropyrimidin-4-yl)amino)benzamide

Refernces

• 1、 Rayatzadeh, Ayeh,Haghipour, Sirous. "Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica". . p. 103 - 107. Retrieved 2021/02/05.
• 2、 Jaganmohan, Chikkanti,Vinay Kumar,Venkateshwarlu,Mohanty, Sandeep,Kumar, Jaydeep,Venkateswara Rao,Raghunadh, Akula,Tadiparthi, Krishnaji. "A novel approach for the synthesis of functionalized hydroxylamino derivative of dihydroquinazolinones". supporting information. p. 2163 - 2170. Retrieved 2020/06/10.