1,2,3,4-Tetrahydroisoquinolin-5-amine

Base Information Edit

Chemical Name:1,2,3,4-Tetrahydroisoquinolin-5-amine
CAS No.:115955-90-3
Molecular Formula:C9H12N2
Molecular Weight:148.208
Hs Code.:2933499090
European Community (EC) Number:626-964-8
ChEMBL ID:CHEMBL3237624
DSSTox Substance ID:DTXSID50584421
Wikidata:Q27452716
Mol file:115955-90-3.mol

Synonyms:115955-90-3;1,2,3,4-Tetrahydroisoquinolin-5-amine;5-Amino-1,2,3,4-tetrahydroisoquinoline;1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-YLAMINE;CHEMBL3237624;5-ISOQUINOLINAMINE, 1,2,3,4-TETRAHYDRO-;1,2,3,4-Tetrahydro-5-aminoisoquinoline;SCHEMBL329571;DTXSID50584421;ZSHCQIHYOFRGNI-UHFFFAOYSA-N;AMY21279;BDBM50008914;MFCD02684185;AKOS006348055;AB12578;TS-01948;CS-0270717;5-Amino-1,2,3,4-tetrahydroisoquinoline, 98%;EN300-1225085;J-003347;Q27452716;F1967-3213;24W

Suppliers and Price of 1,2,3,4-Tetrahydroisoquinolin-5-amine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2,3,4-Tetrahydroisoquinolin-5-amine
100mg
$ 70.00

SynQuest Laboratories
5-Amino-1,2,3,4-tetrahydroisoquinoline
1 g
$ 152.00

Sigma-Aldrich
5-Amino-1,2,3,4-tetrahydroisoquinoline 98%
5g
$ 420.00

Matrix Scientific
1,2,3,4-Tetrahydroisoquinolin-5-amine 97%
1g
$ 125.00

Matrix Scientific
1,2,3,4-Tetrahydroisoquinolin-5-amine 97%
5g
$ 375.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-5-ylamine 96%
5g
$ 598.00

J&W Pharmlab
1,2,3,4-Tetrahydro-isoquinolin-5-ylamine 96%
1g
$ 198.00

Crysdot
1,2,3,4-Tetrahydroisoquinolin-5-amine 95+%
5g
$ 194.00

Chemenu
1,2,3,4-Tetrahydroisoquinolin-5-amine 95%
5g
$ 297.00

Apolloscientific
5-Amino-1,2,3,4-tetrahydroisoquinoline
1g
$ 129.00

Total 23 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydroisoquinolin-5-amine Edit

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Melting Point:153-155 °C(lit.)
Refractive Index:1.6
Boiling Point:437.5 °C at 760 mmHg
PKA:9.57±0.20(Predicted)
Flash Point:218.4 °C
PSA：38.05000
Density:1.636 g/cm³
LogP:1.82450
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:148.100048391
Heavy Atom Count:11
Complexity:136

Purity/Quality:

98% ^*data from raw suppliers

1,2,3,4-Tetrahydroisoquinolin-5-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=C1C(=CC=C2)N
Uses 1,2,3,4-Tetrahydroisoquinolin-5-amine is used in preparation Quinolinyl and Quinazolinyl Benzenesulfamides and analogs as ectonucleotide ENPP-1 inhibitors as antitumor antiviral.

Technology Process of 1,2,3,4-Tetrahydroisoquinolin-5-amine

There total 6 articles about 1,2,3,4-Tetrahydroisoquinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1125-60-6
isoquinolin-5-ylamine

: 115955-90-3
1,2,3,4-tetrahydroisoquinolin-5-amine

Guidance literature:: With hydrogen; In n-heptane; at 150 ℃; for 72h; under 22502.3 Torr; chemoselective reaction; Catalytic behavior; Sealed tube;
DOI:10.1021/acs.inorgchem.1c03098

Reference yield: 86.4%

: 607-32-9
5-nitroisoquinoline

: 1125-60-6
isoquinolin-5-ylamine

: 115955-90-3
1,2,3,4-tetrahydroisoquinolin-5-amine

Guidance literature:: With 1 % platinum on carbon; hydrogen; In tetrahydrofuran; at 40 ℃; under 15001.5 Torr; Temperature; Pressure; Flow reactor;
DOI:10.1021/acs.oprd.1c00164