N-(1-benzylpiperidin-4-yl)dipropylamine

Base Information

• Chemical Name: N-(1-benzylpiperidin-4-yl)dipropylamine
• CAS No.: 1259401-76-7
• Molecular Formula: C₁₈H₃₀N₂
• Molecular Weight: 274.45
• Mol file: 1259401-76-7.mol

Synonyms:N-(1-benzylpiperidin-4-yl)dipropylamine

Chemical Property of N-(1-benzylpiperidin-4-yl)dipropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-benzylpiperidin-4-yl)dipropylamine

There total 4 articles about N-(1-benzylpiperidin-4-yl)dipropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

propyl bromide (106-94-5) + N-(1-benzylpiperidin-4-yl)propylamine (160358-05-4) → N-(1-benzylpiperidin-4-yl)dipropylamine (1259401-76-7)

Guidance literature:

With potassium iodide; potassium hydroxide; In N,N-dimethyl-formamide; for 48h; Reflux;

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) + propionaldehyde (123-38-6) → N-(1-benzylpiperidin-4-yl)dipropylamine (1259401-76-7)

Guidance literature:

With trimethyl orthoformate; In methanol; at 20 ℃; for 14h;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-(1-benzylpiperidin-4-yl)dipropylamine (1259401-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / toluene / 48 h / Reflux

2: borohydride / methanol / 4 h / 20 °C

3: potassium hydroxide; potassium iodide / N,N-dimethyl-formamide / 48 h / Reflux

With formic acid; potassium iodide; potassium hydroxide; In methanol; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-amino-1-benzylpiperidine

propionaldehyde

1-phenylmethyl-4-piperidone

propyl bromide

Downstream raw materials:

N-(piperidin-4-yl)dipropylamine

Refernces

• 1、 -. "AMINE COMPOUNDS AND USE THEREOF". Page/Page column 51. . Retrieved 2010/02/12.