2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine

Base Information

• Chemical Name: 2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine
• CAS No.: 115749-42-3
• Molecular Formula: C₁₀H₇N₃S
• Molecular Weight: 201.252
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20364131
• Wikidata: Q82147913
• Mol file: 115749-42-3.mol

Synonyms:115749-42-3;2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine;2-(thiophen-2-yl)imidazo[1,2-a]pyrimidine;2-thiophen-2-ylimidazo[1,2-a]pyrimidine;MFCD03462375;DTXSID20364131;BBL100069;STK903379;AKOS002165743;MS-20171;EN300-258370;Z57221097;Fmoc-(R)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionicacid

Chemical Property of 2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine

Chemical Property:

• Refractive Index: 1.762
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 58.43000
• Density: 1.4g/cm³
• LogP: 2.45780
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 201.03606841
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

97% ^*data from raw suppliers

2-(Thiophen-2-yl)imidazo[1,2-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=C(N=C2N=C1)C3=CC=CS3

Technology Process of 2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine

There total 2 articles about 2-Thiophen-2-yl-imidazo[1,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2-aminopyrimidine (109-12-6) + 2-Bromoacetylthiophene (10531-41-6) → (thienyl-2)-2 imidazo<1,2-a>pyrimidine (115749-42-3)

Guidance literature:

In acetonitrile; 1.) room temp., 1 h, 2.) reflux, 24 h;

DOI:10.1016/0223-5234(87)90036-5

Reference yield:

2-aminopyrimidine (109-12-6) + 2,4-dinitro-benzenesulfonic acid 2-oxo-2-thiophen-2-yl-ethyl ester → (thienyl-2)-2 imidazo<1,2-a>pyrimidine (115749-42-3)

Guidance literature:

With sodium carbonate; In poly(ethylene glycol-400); at 20 ℃; for 0.5h;

DOI:10.1002/jccs.200900094

upstream raw materials:

2-aminopyrimidine

2-Bromoacetylthiophene

Refernces

• 1、 Louiseau,Payard,Grassy,Dornelles Pinto,Advenier,Gnassounou,Adam. "New azaindolizine-type compounds: In vitro study of the prevention of bronchospasms". . p. 457 - 462. Retrieved 2007/10/02.