Technology Process of dibenzylphosphoryl 2,3,4-tri-O-benzoyl-6-deoxy-6-fluoro-β-L-galactopyranoside
There total 4 articles about dibenzylphosphoryl 2,3,4-tri-O-benzoyl-6-deoxy-6-fluoro-β-L-galactopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2,3,4-tetra-O-benzoyl-6-deoxy-6-fluoro-L-galactopyranoside;
With
hydrogen bromide; acetic acid;
In
dichloromethane;
at 20 ℃;
for 3h;
phosphoric acid dibenzyl ester;
With
3 Angstroem MS; silver carbonate;
In
diethyl ether; dichloromethane; acetonitrile;
at 20 ℃;
for 15h;
DOI:10.1016/S0968-0896(00)00139-5
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / 16 h / 20 °C
2.1: 30 percent HBr; AcOH / CH2Cl2 / 3 h / 20 °C
2.2: 75 percent / Ag2CO3; 3 Angstroem MS / CH2Cl2; diethyl ether; acetonitrile / 15 h / 20 °C
With
hydrogen bromide; acetic acid;
In
pyridine; dichloromethane;
1.1: Acylation / 2.1: Bromination / 2.2: Substitution;
DOI:10.1016/S0968-0896(00)00139-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 77 percent / collidine; DAST / CH2Cl2 / 6 h / Heating
2.1: 68 percent / AcOH / H2O
3.1: pyridine / 16 h / 20 °C
4.1: 30 percent HBr; AcOH / CH2Cl2 / 3 h / 20 °C
4.2: 75 percent / Ag2CO3; 3 Angstroem MS / CH2Cl2; diethyl ether; acetonitrile / 15 h / 20 °C
With
2,3,5-trimethyl-pyridine; hydrogen bromide; acetic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid;
In
pyridine; dichloromethane; water;
1.1: Fluorination / 2.1: Ring cleavage / 3.1: Acylation / 4.1: Bromination / 4.2: Substitution;
DOI:10.1016/S0968-0896(00)00139-5
