4-BROMOBENZYLZINC BROMIDE

Base Information

• Chemical Name: 4-BROMOBENZYLZINC BROMIDE
• CAS No.: 115055-85-1
• Molecular Formula: C₇H₆Br₂Zn
• Molecular Weight: 315.323
• Hs Code.: 29319090
• Mol file: 115055-85-1.mol

Synonyms:4-BROMOBENZYLZINC BROMIDE;4-BROMOBENZYLZINC BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;4-bromobenzylzinc bromide solution

Chemical Property of 4-BROMOBENZYLZINC BROMIDE

Chemical Property:

• Vapor Pressure: 1.04mmHg at 25°C
• Boiling Point: 183.8°C at 760 mmHg
• Flash Point: 1℉
• PSA: 0.00000
• Density: 1.015g/mLat25℃
• LogP: 3.60790
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromobenzylzinc bromide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 14-19-22-36/38-40-36/37-11
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMOBENZYLZINC BROMIDE

There total 2 articles about 4-BROMOBENZYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) + zinc (7440-66-6) → bromo-[(4-bromophenyl)methyl]zinc (115055-85-1)

Guidance literature:

zinc; With ethylene dibromide; In tetrahydrofuran; at 65 ℃; for 0.0833333h; Inert atmosphere;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at 0 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jo401640c

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → bromo-[(4-bromophenyl)methyl]zinc (115055-85-1)

Guidance literature:

In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.jfluchem.2014.08.021

Reference yield: 80.0%

[bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + bromo-[(4-bromophenyl)methyl]zinc (115055-85-1) → 1-bromo-4-(2,2-difluoro-2-iodoethyl)benzene (1422038-98-9)

Guidance literature:

bromo-[(4-bromophenyl)methyl]zinc; With sodium acetate; In acetonitrile; at -25 - 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

[bromo(difluoro)methyl]-trimethyl-silane; In acetonitrile; at -25 - 20 ℃; for 18h; Inert atmosphere; Schlenk technique;

With iodine; In acetonitrile; at -25 - 20 ℃; for 5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol400122k

upstream raw materials:

1-bromomethyl-4-bromobenzene

zinc

Downstream raw materials:

1-benzyloxy-4-[(4-bromophenyl)methyl]-1,8-naphthyridin-2-one

α-{4-[2-(4-methyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

α-{4-[2-(1-piperidinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

Refernces

• 1、 Palao, Eduardo,López, Enol,Torres-Moya, Iván,De La Hoz, Antonio,Díaz-Ortiz, ángel,Alcázar, Jesús. "Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling". supporting information. p. 8210 - 8213. Retrieved 2020/08/17.
• 2、 Abou Nakad,Bolze,Specht. "o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties". . p. 6115 - 6122. Retrieved 2018/09/06.