(E)-2,6-di-tert-butyl-4-styrylphenol

Base Information

• Chemical Name: (E)-2,6-di-tert-butyl-4-styrylphenol
• CAS No.: 21449-69-4
• Molecular Formula: C₂₂H₂₈O
• Molecular Weight: 308.464
• Mol file: 21449-69-4.mol

Synonyms:(E)-2,6-di-tert-butyl-4-styrylphenol

Chemical Property of (E)-2,6-di-tert-butyl-4-styrylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-2,6-di-tert-butyl-4-styrylphenol

There total 9 articles about (E)-2,6-di-tert-butyl-4-styrylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) + 3,5-di-t-butyl-4-hydroxybenzaldehyde (1620-98-0) → (E)-2,6-di-tert-butyl-4-styrylphenol (21449-69-4)

Guidance literature:

With piperidine; In dichloromethane; Heating;

DOI:10.1021/jm00121a021

Reference yield:

1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-propanol (20017-35-0) → (E)-2,6-di-tert-butyl-4-styrylphenol (21449-69-4)

Guidance literature:

Multi-step reaction with 7 steps

1: CH₃COOH / 0.17 h / Heating

2: 43 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

3: diethyl ether / 2.5 h / Heating

4: CH₃COOH / 0.17 h / Heating

5: 80 percent Spectr_. / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

6: diethyl ether / 2.5 h / Heating

7: CH₃COOH / 0.17 h / Heating

With potassium tert-butylate; oxygen; acetic acid; In diethyl ether; hexane; tert-butyl alcohol;

DOI:10.1021/jo00362a018

Reference yield:

2,6-di-tert-butyl-4-(1-hydroxy-2-methylpropyl)phenol (20359-84-6) → (E)-2,6-di-tert-butyl-4-styrylphenol (21449-69-4)

Guidance literature:

Multi-step reaction with 7 steps

1: CH₃COOH / 0.17 h / Heating

2: 80 percent Spectr_. / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

3: diethyl ether / 2.5 h / Heating

4: CH₃COOH / 0.17 h / Heating

5: 43 percent / t-BuOK, O₂ / 2-methyl-propan-2-ol; hexane / 0.5 h / 0 °C

6: diethyl ether / 2.5 h / Heating

7: CH₃COOH / 0.17 h / Heating

With potassium tert-butylate; oxygen; acetic acid; In diethyl ether; hexane; tert-butyl alcohol;

DOI:10.1021/jo00362a018

upstream raw materials:

1-(3,5-Di-tert.-butyl-4-hydroxy-phenyl)-2-phenyl-aethanol

phenylacetic acid

3,5-di-t-butyl-4-hydroxybenzaldehyde

2,6-di-tert-butyl-4-(1-hydroxy-2-methylpropyl)phenol

Downstream raw materials:

2,6-Di-tert-butyl-4-((1S,2S)-2-hydroxy-1-methoxy-2-phenyl-ethyl)-phenol

2,6-Di-tert-butyl-4-(2-hydroxy-1-methoxy-2-phenyl-ethyl)-phenol

2,6-Di-tert-butyl-4-(2-hydroxy-2-phenyl-ethylidene)-cyclohexa-2,5-dienone

1,1-dimethyl-2-(3',5'-di-t-butyl-4'-hydroxyphenyl)ethene

Refernces

• 1、 Lazer, Edward S.,Wong, Hin-Chor,Possanza, Genus J.,Graham, Anne G.,Farina, Peter R.. "Antiinflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl)phenols". . p. 100 - 104. Retrieved 2007/10/02.