thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester

Base Information

• Chemical Name: thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester
• CAS No.: 353759-03-2
• Molecular Formula: C₂₂H₂₅ClN₂O₄S
• Molecular Weight: 448.971
• Mol file: 353759-03-2.mol

Synonyms:thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester

Chemical Property of thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester

There total 1 articles about thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

thiocarbonic acid S-ethyl ester O-iodomethyl ester (133217-42-2) + halofenozide (112226-61-6) → thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester (353759-03-2)

Guidance literature:

halofenozide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 2h;

thiocarbonic acid S-ethyl ester O-iodomethyl ester; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-2002-19296

Reference yield: 88.0%

thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester (353759-03-2) → benzoic acid N-tert-butyl-N'-(4-chlorobenzoyl)-N'-chloromethylhydrazide (421568-94-7)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-2002-19296

Reference yield:

thiocarbonic acid O-[N'-benzoyl-N'-tert-butyl-N-(4-chlorobenzoyl)hydrazino-methyl] ester S-ethyl ester (353759-03-2) → formic acid N'-benzoyl-N'-tert-butyl-N-(4-chloro-benzoyl)-hydrazinomethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / SO₂Cl₂ / CH₂Cl₂ / 1 h / 20 °C

2: DIEA / tetrahydrofuran / 20 °C

With sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2002-19296

upstream raw materials:

thiocarbonic acid S-ethyl ester O-iodomethyl ester

halofenozide

Downstream raw materials:

benzoic acid N-tert-butyl-N'-(4-chlorobenzoyl)-N'-chloromethylhydrazide

Refernces