Technology Process of tert-butyl ((1R,2S)-3-{[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate
There total 4 articles about tert-butyl ((1R,2S)-3-{[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium trifluoromethanesulfonate;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene / Heating / reflux
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C
3.2: 1 h
4.1: lithium trifluoromethanesulfonate / acetonitrile
With
lithium aluminium tetrahydride; hydrogen; lithium trifluoromethanesulfonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dicyclohexyl-carbodiimide / dmap / dichloromethane / 0 - 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.25 h / -70 - -65 °C
2.2: 0.33 h / -65 - -20 °C
3.1: potassium hydroxide / ethanol / 20 °C
4.1: lithium trifluoromethanesulfonate / acetonitrile
With
potassium hydroxide; lithium trifluoromethanesulfonate; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
dmap;
In
tetrahydrofuran; hexanes; ethanol; dichloromethane; acetonitrile;