1-propyl-2-dimethylaminomethylbenzene

Base Information

• Chemical Name: 1-propyl-2-dimethylaminomethylbenzene
• CAS No.: 133302-85-9
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.29
• Mol file: 133302-85-9.mol

Synonyms:1-propyl-2-dimethylaminomethylbenzene

Chemical Property of 1-propyl-2-dimethylaminomethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-propyl-2-dimethylaminomethylbenzene

There total 5 articles about 1-propyl-2-dimethylaminomethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C12H19(2)HN(1+)*Cl(1-) (80150-89-6,80150-90-9) → 1-propyl-2-dimethylaminomethylbenzene (133302-85-9)

Guidance literature:

With t-C₄H₉)K; In tert-butyl alcohol; at 55 ℃; for 5h;

Reference yield:

Trimethyl-1-phenyl-propyl-ammonium methiodide (95844-69-2) → 1-propenylbenzene (873-66-5) + cis-1-phenyl-1-propylene (766-90-5) + α-ethyl-N,N-dimethylbenzenemethanamine (3330-05-0) + 1-propyl-2-dimethylaminomethylbenzene (133302-85-9) + trimethylamine (75-50-3)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 55 ℃; for 5h; Mechanism; Product distribution; other base, other solvents;

Reference yield:

α-ethylbenzyldimethyl(trimethylsilylmethyl)ammonium iodide (133302-73-5) → 1-propenylbenzene (873-66-5) + N,N-Dimethyl-2-phenyl-butylamin (33132-91-1) + 1-propyl-2-dimethylaminomethylbenzene (133302-85-9)

Guidance literature:

With potassium hydroxide; cesium fluoride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) DMF, 10 deg C, 0,5 h, 2.) EtOH, 60 deg C, 24 h;

DOI:10.1055/s-1991-26393

upstream raw materials:

Trimethyl-1-phenyl-propyl-ammonium methiodide

C₁₂H₁₉⁽²⁾HN⁽¹⁺⁾*Cl^(1-)

α-ethylbenzyldimethyl(trimethylsilylmethyl)ammonium iodide

1-propenylbenzene

Refernces

• 1、 Machkova, Zuzana,Zavada, Jiri. "THE EFFECT OF PHENYL SUBSTITUENTS ON ELIMINATION STEREOCHEMISTRY: A MECHANISTIC MANIFOLD IN ALKOXIDE PROMOTED DECOMPOSITION OF 1-PHENYL-1-PROPYLTRIMETHYLAMMONIUM ION". . p. 833 - 849. Retrieved 2007/10/02.