5-CHLORO-1H-INDOL-3-METHYLAMINE

Base Information

• Chemical Name: 5-CHLORO-1H-INDOL-3-METHYLAMINE
• CAS No.: 113188-83-3
• Molecular Formula: C₉H₉ClN₂
• Molecular Weight: 180.637
• Hs Code.: 2933990090
• Mol file: 113188-83-3.mol

Synonyms:5-Chloro-1H-indole-3-methanamine;

Chemical Property of 5-CHLORO-1H-INDOL-3-METHYLAMINE

Chemical Property:

• Boiling Point: 369.8 °C at 760 mmHg
• PKA: 16.22±0.30(Predicted)
• Flash Point: 177.4 °C
• PSA: 41.81000
• Density: 1.349g/cm³
• LogP: 2.98030
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-chloro-1H-indol-3-methylamine 96 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-1H-INDOL-3-METHYLAMINE

There total 2 articles about 5-CHLORO-1H-INDOL-3-METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-1H-indole-3-carbaldehyde oxime (1261024-31-0) → (5-chloro-1H-indol-3-yl)methanamine (113188-83-3)

Guidance literature:

5-chloro-1H-indole-3-carbaldehyde oxime; With acetic acid; zinc; at 20 ℃; for 14h;

With sodium carbonate; In water; ethyl acetate;

Reference yield:

5-chloro-1H-indole-3-carboxaldehyde (827-01-0) → (5-chloro-1H-indol-3-yl)methanamine (113188-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 3.5 h / Reflux

2: zinc; acetic acid / 14 h / 20 °C

With hydroxylamine hydrochloride; sodium acetate; acetic acid; zinc; In ethanol;

Reference yield:

(5-chloro-1H-indol-3-yl)methanamine (113188-83-3) + benzoyl chloride (98-88-4) → C16H13ClN2O (1597410-11-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol5007532

upstream raw materials:

5-chloro-1H-indole-3-carbaldehyde oxime

5-chloro-1H-indole-3-carboxaldehyde

Downstream raw materials:

C₁₆H₁₃ClN₂O

(4aS,9aS)-4a,6-dichloro-2-phenyl-9-tosyl-4,4a,9,9a-tetrahydro-[1,3]oxazino[6,5-b]indole

Refernces

• 1、 Karuvalam, Ranjith Pakkath,Pakkath, Rajeesh,Haridas, Karickal Raman,Rishikesan, Rathnasamy,Kumari, Nalilu Suchetha. "Synthesis, characterization, and SAR studies of new (1H-indol-3-yl)alkyl-3- (1H-indol-3-yl)propanamide derivatives as possible antimicrobial and antitubercular agents". . p. 4437 - 4454. Retrieved 2013/09/02.
• 2、 -. "NOVEL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES". Paragraph 0521-0522. . Retrieved 2013/11/06.