4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN

Base Information

• Chemical Name: 4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN
• CAS No.: 113018-98-7
• Molecular Formula: C₁₀H₅ClO₄
• Molecular Weight: 224.6
• Hs Code.: 2932209090
• Mol file: 113018-98-7.mol

Synonyms:4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN;6-CHLORO-4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE;SALOR-INT L481521-1EA

Chemical Property of 4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN

Chemical Property:

• Boiling Point: 442.4±45.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 67.51000
• Density: 1.746±0.06 g/cm3(Predicted)
• LogP: 1.96450

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-CHLORO-4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN

There total 1 articles about 4-HYDROXY-6-CHLORO-3-FORMYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-4-oxo-4H-chromene-3-carboxylic acid (51085-92-8) → 6-Chloro-4-hydroxy-2-oxo-2H-chromene-3-carbaldehyde (113018-98-7)

Guidance literature:

With methanol; sodium hydroxide; sulfuric acid; Yield given. Multistep reaction; 1) 1-3h, reflux, 2) 20 deg C, 15 - 30 min;

Reference yield: 55.0%

6-Chloro-4-hydroxy-2-oxo-2H-chromene-3-carbaldehyde (113018-98-7) + ethyl 3-aminobut-2-enoate (626-34-6) → 3-(5'-Chlor-2'-hydroxybenzoyl)-6-methyl-2H-pyridon-5-carbonsaeureethylester

Guidance literature:

In N,N-dimethyl-formamide; for 15h; Ambient temperature;

DOI:10.1002/ardp.19873200512

Reference yield: 45.0%

4-Aminopent-3-en-2-one (1118-66-7) + 6-Chloro-4-hydroxy-2-oxo-2H-chromene-3-carbaldehyde (113018-98-7) → 5-Acetyl-3-(5'-chlor-2'-hydroxybenzoyl)-6-methyl-2H-pyridon

Guidance literature:

In N,N-dimethyl-formamide; for 15h; Ambient temperature;

DOI:10.1002/ardp.19873200512

upstream raw materials:

6-chloro-4-oxo-4H-chromene-3-carboxylic acid

Refernces