ALPHA-CHLORO-9-ANTHRALDOXIME

Base Information

• Chemical Name: ALPHA-CHLORO-9-ANTHRALDOXIME
• CAS No.: 113003-49-9
• Molecular Formula: C15H10ClNO
• Molecular Weight: 255.7
• Mol file: 113003-49-9.mol

Synonyms:ALPHA-CHLORO-9-ANTHRALDOXIME;-Chloro-9-anthraldoxime;A-CHLORO-9-ANTHRALDOXIME

Chemical Property of ALPHA-CHLORO-9-ANTHRALDOXIME

Chemical Property:

• Vapor Pressure: 3.64E-10mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 483.6 °C at 760 mmHg
• PKA: 10.51±0.70(Predicted)
• Flash Point: 246.3 °C
• PSA: 32.59000
• Density: 1.27 g/cm³
• LogP: 4.36760

Purity/Quality:

98%min ^*data from raw suppliers

α-Chloro-9-anthraldoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-CHLORO-9-ANTHRALDOXIME

There total 2 articles about ALPHA-CHLORO-9-ANTHRALDOXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-anthracenealdehyde oxime (18004-57-4) → 9-anthracylhydroximoyl chloride (113003-49-9)

Guidance literature:

With pyridine; N-chloro-succinimide; In chloroform; for 2h; Ambient temperature;

DOI:10.1080/00397919408011744

Reference yield:

9-anthracene aldehyde (642-31-9) → 9-anthracylhydroximoyl chloride (113003-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / ethanol; water / 0.08 h

1.2: pH 7

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.17 h / 60 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1080/14786419.2019.1677649

Reference yield: 67.0%

(4-tert-butylphenoxy)acetonitrile (50635-24-0) + 9-anthracylhydroximoyl chloride (113003-49-9) → C27H24N2O2

Guidance literature:

With triethylamine; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/asia.201403265

upstream raw materials:

9-anthracenealdehyde oxime

9-anthracene aldehyde

Refernces

• 1、 Pan, Hongmei,Lu, Tong,Wu, Xuedan,Gu, Chengwen,Tao, Naili,Zhang, Biao,Wang, Ao,Chen, Guangmei,Zhang, Kehua,Cheng, Jie,Jin, Jie. "Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction". supporting information. p. 2360 - 2364. Retrieved 2019/11/11.
• 2、 Ismail, Tabasum,Shafi, Syed,Singh, Parvinder Pal,Qazi, Naveed Ahmed,Sawant, Sanghapal D.,Ali, Intzar,Khan, Inshad Ali,Kumar,Qazi, Ghulam Nabi,Alam, M. Sarwar. "Biologically active hydroxymoyl chlorides as antifungal agents". . p. 740 - 747. Retrieved 2008/12/20.