Technology Process of 1-O-{-10-[4-(pyrene-1-yl)-butoxy]-decyl}-2-O-benzoyl-rac-glycero-3-phosphocholine
There total 7 articles about 1-O-{-10-[4-(pyrene-1-yl)-butoxy]-decyl}-2-O-benzoyl-rac-glycero-3-phosphocholine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C42H52BrO8P; trimethylamine;
In
ethanol; chloroform; isopropyl alcohol; acetonitrile;
at 50 ℃;
With
formic acid;
In
methanol; chloroform;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / toluene / 1 h / 100 °C
1.2: 16 h
2.1: potassium tert-butylate / toluene / 1 h / Heating / reflux
2.2: 18 h / 20 °C
3.1: trifluoroacetic acid / toluene / 1 h / 0 °C
4.1: acetonitrile / 18 h
5.1: pyridine / dichloromethane / 1 h / 0 - 20 °C
6.1: methanol; boron trifluoride / dichloromethane / -10 °C
7.1: pyridine / dichloromethane / 20 °C / Heating / reflux
8.1: water / 1 h / 0 °C
9.1: ethanol; chloroform; isopropyl alcohol; acetonitrile / 50 °C
With
pyridine; methanol; boron trifluoride; potassium tert-butylate; water; trifluoroacetic acid;
In
ethanol; dichloromethane; chloroform; isopropyl alcohol; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: thionyl chloride / 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3.1: potassium tert-butylate / toluene / 1 h / 100 °C
3.2: 16 h
4.1: potassium tert-butylate / toluene / 1 h / Heating / reflux
4.2: 18 h / 20 °C
5.1: trifluoroacetic acid / toluene / 1 h / 0 °C
6.1: acetonitrile / 18 h
7.1: pyridine / dichloromethane / 1 h / 0 - 20 °C
8.1: methanol; boron trifluoride / dichloromethane / -10 °C
9.1: pyridine / dichloromethane / 20 °C / Heating / reflux
10.1: water / 1 h / 0 °C
11.1: ethanol; chloroform; isopropyl alcohol; acetonitrile / 50 °C
With
pyridine; methanol; lithium aluminium tetrahydride; thionyl chloride; boron trifluoride; potassium tert-butylate; water; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; isopropyl alcohol; toluene; acetonitrile;