1-phenyl (O,1-⁽²⁾H₂)ethanol

Base Information

• Chemical Name: 1-phenyl (O,1-⁽²⁾H₂)ethanol
• CAS No.: 115976-33-5
• Molecular Formula: C₈H₁₀O
• Molecular Weight: 124.151
• Mol file: 115976-33-5.mol

Synonyms:1-phenyl (O,1-⁽²⁾H₂)ethanol

Chemical Property of 1-phenyl (O,1-⁽²⁾H₂)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl (O,1-⁽²⁾H₂)ethanol

There total 9 articles about 1-phenyl (O,1-⁽²⁾H₂)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetophenone p-toluenesulfonylhydrazone (4545-21-5) → 1-phenyl (O,1-(2)H2)ethanol (115976-33-5)

Guidance literature:

With water-d2; potassium carbonate; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1055/s-0031-1290372

Reference yield: 93.0%

acetophenone (98-86-2) → 1-phenyl (O,1-(2)H2)ethanol (115976-33-5)

Guidance literature:

With d8-isopropanol; [Ir(1-(1′-methylpyrazole)-3-(4′-methylphenyl)triazenide)Cp*Cl]; at 90 ℃; for 39h; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Glovebox;

DOI:10.1016/j.ica.2020.119551

Reference yield: 88.0%

d8-isopropanol (22739-76-0) + acetophenone (98-86-2) → [(2)H6]acetone (666-52-4) + 1-phenyl (O,1-(2)H2)ethanol (115976-33-5)

Guidance literature:

With tetrakis[3,5-bis(trifluoromethyl)phenyl]boric acid bis(diethyl ether) complex; (bis[(2-dicyclohexylphosphino)ethyl]amine)cobalt(II)(CH₂SiMe₃); In tetrahydrofuran; at 25 ℃; for 24h; Solvent; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/c3cc45900d

upstream raw materials:

acetophenone

(S)-1-phenylethanol

(R)-1-phenylethanol

1-Phenylethanol

Downstream raw materials:

acetophenone

7-bromo-2-phenylquinoline

6-chloro-2-phenylquinoline

7-chloro-2-phenyl-quinoline

Refernces

• 1、 Camarena-Diáz, Juan P.,Iglesias, Ana L.,Chávez, Daniel,Aguirre, Gerardo,Grotjahn, Douglas B.,Rheingold, Arnold L.,Parra-Hake, Miguel,Miranda-Soto, Valentín. "Rh(III)Cp? and Ir(III)Cp? Complexes of 1-[(4-Methyl)phenyl]-3-[(2-methyl-4′-R)imidazol-1-yl]triazenide (R = t-Bu or H): Synthesis, Structure, and Catalytic Activity". . p. 844 - 851. Retrieved 2019.
• 2、 Medrano-Castillo, Layla J.,Collazo-Flores, Miguel á.,Camarena-Díaz, Juan P.,Correa-Ayala, Erick,Chávez, Daniel,Grotjahn, Douglas B.,Rheingold, Arnold L.,Miranda-Soto, Valentín,Parra-Hake, Miguel. "Base-free transfer hydrogenation of aryl-ketones, alkyl-ketones and alkenones catalyzed by an IrIIICp* complex bearing a triazenide ligand functionalized with pyrazole". . . Retrieved 2020/03/13.
• 3、 Zhang, Guoqi,Hanson, Susan K.. "Cobalt-catalyzed transfer hydrogenation of C=O and C=N bonds". supporting information. p. 10151 - 10153. Retrieved 2013/10/22.