Pyridine, 4-(ethenyloxy)- (9CI)

Base Information

• Chemical Name: Pyridine, 4-(ethenyloxy)- (9CI)
• CAS No.: 112342-76-4
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121.139
• Mol file: 112342-76-4.mol

Synonyms:4-(Vinyloxy)pyridine

Chemical Property of Pyridine, 4-(ethenyloxy)- (9CI)

Chemical Property:

• Boiling Point: 180.9±13.0 °C(Predicted)
• PKA: 5.79±0.26(Predicted)
• PSA: 22.12000
• Density: 1.024±0.06 g/cm3(Predicted)
• LogP: 1.60390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 4-(ethenyloxy)- (9CI)

There total 4 articles about Pyridine, 4-(ethenyloxy)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloroethoxy)pyridine hydrochloride → 4-vinyloxypyridine (112342-76-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.11.061

Reference yield:

4-bromopyridin (1120-87-2) → 4-vinyloxypyridine (112342-76-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; copper dichloride / 16 h / 20 - 130 °C / Inert atmosphere; Sealed tube

2: thionyl chloride / dichloromethane / 10 h / 60 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With thionyl chloride; sodium hydride; potassium carbonate; copper dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2016.11.061

Reference yield:

2-(pyridin-4-yloxy)ethan-1-ol (86450-38-6) → 4-vinyloxypyridine (112342-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 10 h / 60 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2016.11.061

upstream raw materials:

4-bromopyridin

2-(pyridin-4-yloxy)ethan-1-ol

Refernces