N-(4-nitrophenyl)-N'-acetylthiourea

Base Information

• Chemical Name: N-(4-nitrophenyl)-N'-acetylthiourea
• CAS No.: 66934-12-1
• Molecular Formula: C₉H₉N₃O₃S
• Molecular Weight: 239.255
• Mol file: 66934-12-1.mol

Synonyms:N-(4-nitrophenyl)-N'-acetylthiourea

Chemical Property of N-(4-nitrophenyl)-N'-acetylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-nitrophenyl)-N'-acetylthiourea

There total 4 articles about N-(4-nitrophenyl)-N'-acetylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

potassium thioacyanate (333-20-0) + 4-nitro-aniline (100-01-6,104810-17-5) + acetyl chloride (75-36-5) → N-(4-nitrophenyl)-N'-acetylthiourea (66934-12-1)

Guidance literature:

potassium thioacyanate; acetyl chloride; In water; acetone; for 3h;

4-nitro-aniline; In water; acetone; for 5h; Reflux;

DOI:10.1016/j.molstruc.2015.06.024

Reference yield:

ammonium thiocyanate (1147550-11-5) + 4-nitro-aniline (100-01-6,104810-17-5) + acetyl chloride (75-36-5) → N-(4-nitrophenyl)-N'-acetylthiourea (66934-12-1)

Guidance literature:

ammonium thiocyanate; acetyl chloride; With PEG-400; In dichloromethane; at 20 ℃; for 3h;

4-nitro-aniline; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.cclet.2015.08.001

Reference yield:

(Z)-trimethylsilyl N-trimethylsilylacetimidate (10416-59-8,132255-83-5) + p-nitrophenyl isothiocyanate (2131-61-5) → N-(4-nitrophenyl)-N'-acetylthiourea (66934-12-1)

Guidance literature:

With methanol; Yield given. Multistep reaction; 1.) 24 h;

upstream raw materials:

(Z)-trimethylsilyl N-trimethylsilylacetimidate

p-nitrophenyl isothiocyanate

potassium thioacyanate

4-nitro-aniline

Downstream raw materials:

N-(6-nitro-1,3-benzothiazol-2-yl)acetamide

Refernces

• 1、 Wang, Jun-Ke,Zong, Ying-Xiao,Wang, Xi-Cun,Hu, Yu-Lai,Yue, Guo-Ren. "Synthesis of N-benzothiazol-2-yl-amides by Pd-catalyzed C(sp2)-H functionalization". . p. 1376 - 1380. Retrieved 2015/10/28.