Technology Process of (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one
There total 17 articles about (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetone;
for 4h;
Ambient temperature;
DOI:10.1139/v97-136
- Guidance literature:
-
With
sodium methylate;
In
tetrahydrofuran; methanol;
for 22h;
Heating;
DOI:10.1139/v97-136
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 65 percent / p-toluenesulfonic acid / tetrahydrofuran / 24 h / Heating
2: 1.) LDA / 1.) THF, from 0 deg C, 30 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h
3: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 0.33 h / 2068.6 Torr / Ambient temperature
4: 8 percent / triflic acid / tetrahydrofuran / 14 h / 0 °C
5: 92 percent / LiAlH4 / diethyl ether / 0.17 h / Ambient temperature
6: 1.) NaH, 2.) n-Bu4NI / 1.) THF, 2.) THF, reflux, 22 h
7: 96 percent / 1M aq. HCl / acetone / 4 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethyl acetate; acetone;
DOI:10.1139/v97-136