1-benzyl-2-vinylaziridine

Base Information

• Chemical Name: 1-benzyl-2-vinylaziridine
• CAS No.: 202596-67-6
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.231
• Mol file: 202596-67-6.mol

Synonyms:1-benzyl-2-vinylaziridine

Chemical Property of 1-benzyl-2-vinylaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-benzyl-2-vinylaziridine

There total 8 articles about 1-benzyl-2-vinylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-benzyl-2-aziridine carboxaldehyde (30005-72-2) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-benzyl-2-vinylaziridine (202596-67-6)

Guidance literature:

Methyltriphenylphosphonium bromide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - 0 ℃; for 1.25h; Inert atmosphere;

1-benzyl-2-aziridine carboxaldehyde; In tetrahydrofuran; at -20 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201302029

Reference yield: 62.0%

1-benzylamino-3-buten-2-ol (125582-80-1) → 1-benzyl-2-vinylaziridine (202596-67-6)

Guidance literature:

With triphenylphosphine dibromide 1:1 addition complex; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/ja037450m

Reference yield: 58.0%

1-benzyl-2-aziridine carboxaldehyde (30005-72-2) + methyl-triphenylphosphonium iodide (2065-66-9) → 1-benzyl-2-vinylaziridine (202596-67-6)

Guidance literature:

methyl-triphenylphosphonium iodide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

1-benzyl-2-aziridine carboxaldehyde; In tetrahydrofuran; at -10 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c8ob03029d

upstream raw materials:

1-benzyl-2-aziridine carboxaldehyde

Methylenetriphenylphosphorane

1-benzylamino-3-buten-2-ol

1-benzylaziridine-2-carboxylic acid ethyl ester

Downstream raw materials:

N-benzyl-N-(cyclopropylmethyl)amine

(-)-(S)-1,3-dibenzyl-4-vinyl-imidazolidin-2-one

(+)-(S)-N,N-dibenzyl-but-3-ene-1,2-diamine

(S)-1,3-dibenzyl-4-vinylimidazolidine

Refernces

• 1、 Rivero, Alexandra R.,Fernandez, Israel,Sierra, Miguel A.. "The photochemical reaction of vinylaziridines and vinylazetidines with chromium(0) and molybdenum(0) (fischer) carbene complexes". . p. 1359 - 1366. Retrieved 2014/04/03.
• 2、 Harada, Susumu,Kowase, Noboru,Tabuchi, Nobuhito,Taguchi, Takeo,Dobashi, Yasuo,Dobashi, Akira,Hanzawa, Yuji. "Hydrozirconation of alkenyloxirane derivatives: Preparation of cycloalkylmethanols". . p. 753 - 766. Retrieved 2007/10/03.