2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE
• CAS No.: 2948-92-7
• Molecular Formula: C₁₂H₁₅N₃
• Molecular Weight: 201.271
• Mol file: 2948-92-7.mol

Synonyms:2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole

Chemical Property of 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(Pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE

There total 9 articles about 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

pyrrolidine (123-75-1) + 2-chloromethyl-1H-benzimidazole (4857-04-9) → 2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole (2948-92-7)

Guidance literature:

In ethanol; at 20 ℃; for 50.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2013.07.050

Reference yield: 90.0%

2-(methylsulfonyl)-1H-benzo[d]imidazole (57159-81-6) + 1-((trimethylsilyl)methyl)pyrrolidine (54600-29-2) → 2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole (2948-92-7)

Guidance literature:

With Eosin Y; In methanol; acetonitrile; at 20 ℃; for 3h; Irradiation;

DOI:10.1002/chem.202102124

Reference yield: 64.0%

pyrrolidine (123-75-1) + 2-(bromomethyl)-1-(phenylsulfonyl)-1H-benzo[d]imidazole → 2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole (2948-92-7)

Guidance literature:

With tetrabutylammomium bromide; sodium carbonate; In acetonitrile; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2014.11.066

upstream raw materials:

pyrrolidine

2-chloromethyl-1H-benzimidazole

2-methyl-1-(phenylsulfonyl)-1H-benzo[d]imidazole

2-(Hydroxymethyl)benzimidazole

Refernces

• 1、 Thierry, Thibault,Pfund, Emmanuel,Lequeux, Thierry. "Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y". supporting information. p. 14826 - 14830. Retrieved 2021/10/01.
• 2、 Zhang, Xiaohui,Huang, Ruofeng,Marrot, Jér?me,Coeffard, Vincent,Xiong, Yan. "Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement". . p. 700 - 708. Retrieved 2015/02/02.