methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

Base Information Edit

Chemical Name:methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate
CAS No.:247035-22-9
Molecular Formula:C₁₃H₁₇FN₂O₂
Molecular Weight:252.289
Hs Code.:
Mol file:247035-22-9.mol

Synonyms:methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

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Chemical Property of methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate Edit

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Technology Process of methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

There total 6 articles about methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 247035-20-7
methyl (4-azidopiperidin-1-yl)-3-fluorobenzoate

: 247035-22-9
methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In 1,4-dioxane; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2005.10.061

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 247035-22-9
methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / dimethylsulfoxide / 72 h / 120 °C

2: 92 percent / Et₃N / CH₂Cl₂ / 1 h

3: NaN₃ / dimethylformamide / 5 h / 80 °C

4: 85 percent / H₂; AcOH / Pd/C / dioxane / 4 h / 20 °C

With sodium azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061

Reference yield:

: 247035-19-4
methyl 3-fluoro-4-(4-hydroxypiperidin-1-yl)benzoate

: 247035-22-9
methyl (4-aminopiperidin-1-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 1 h

2: NaN₃ / dimethylformamide / 5 h / 80 °C

3: 85 percent / H₂; AcOH / Pd/C / dioxane / 4 h / 20 °C

With sodium azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061