5-acetyl-6-methyl-1-phenyluracil

Base Information

• Chemical Name: 5-acetyl-6-methyl-1-phenyluracil
• CAS No.: 22293-64-7
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol file: 22293-64-7.mol

Synonyms:5-acetyl-6-methyl-1-phenyluracil

Chemical Property of 5-acetyl-6-methyl-1-phenyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-acetyl-6-methyl-1-phenyluracil

There total 3 articles about 5-acetyl-6-methyl-1-phenyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

4-ethylthio-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one (139057-01-5) → 5-acetyl-6-methyl-1-phenyluracil (22293-64-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Reflux;

DOI:10.1007/s11172-014-0454-5

Reference yield: 15.0%

guanidine acetic acid (593-87-3) + 4-ethylthio-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one (139057-01-5) → 5-acetyl-6-methyl-1-phenyluracil (22293-64-7) + 7-amino-5-methyl-4-methylidene-3-phenyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:

guanidine acetic acid; 4-ethylthio-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one; With sodium methylate; In butan-1-ol; for 2h; Reflux;

With acetic acid; In water; acetonitrile; at 20 ℃; for 0.166667h;

DOI:10.1007/s11172-014-0454-5

Reference yield:

→ 5-acetyl-6-methyl-1-phenyluracil (22293-64-7)

Guidance literature:

4-Anilino-3-(N-ethoxycarbonyl-carbamoyl)-3-penten-2-on, wss. Me3N;

upstream raw materials:

4-ethylthio-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one

guanidine acetic acid

Refernces