4-Amino-1-(4-methoxyphenethyl)piperidine dihydrochloride

Base Information

• Chemical Name: 4-Amino-1-(4-methoxyphenethyl)piperidine dihydrochloride
• CAS No.: 108555-25-5
• Molecular Formula: C₁₄H₂₂N₂O*ClH
• Molecular Weight: 270.802
• DSSTox Substance ID: DTXSID90700764
• Mol file: 108555-25-5.mol

Synonyms:108555-25-5;4-AMINO-1-(4-METHOXYPHENETHYL)PIPERIDINE DIHYDROCHLORIDE;1-[2-(4-methoxyphenyl)ethyl]piperidin-4-amine;dihydrochloride;DTXSID90700764;WJRFXPDCJLQUOJ-UHFFFAOYSA-N;FT-0607093;1-(4-Methoxyphenethyl)piperidin-4-amine dihydrochloride;1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-amine--hydrogen chloride (1/2)

Chemical Property of 4-Amino-1-(4-methoxyphenethyl)piperidine dihydrochloride

Chemical Property:

• PSA: 38.49000
• LogP: 3.90300
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 306.1265688
• Heavy Atom Count: 19
• Complexity: 206

Purity/Quality:

98%Min ^*data from raw suppliers

4-AMINO-1-(4-METHOXYPHENETHYL)PIPERIDINE DIHYDROCHLORIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CCN2CCC(CC2)N.Cl.Cl

Technology Process of 4-Amino-1-(4-methoxyphenethyl)piperidine dihydrochloride

There total 1 articles about 4-Amino-1-(4-methoxyphenethyl)piperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-amino-1-(2-(4-methoxyphenyl)ethyl)piperidine (85098-70-0) + 2-chloro-1-(4-fluorobenzyl)-1H-benzimidazole (84946-20-3) → 1-(4-methoxyphenethyl)piperidin-4-amine hydrochloride (108555-25-5) + astemizole (68844-77-9)

Guidance literature:

In neat (no solvent); at 145 ℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.1c01467

upstream raw materials:

4-amino-1-(2-(4-methoxyphenyl)ethyl)piperidine

2-chloro-1-(4-fluorobenzyl)-1H-benzimidazole

Refernces