4-(TERT-BUTYLDIMETHYLSILYLOXY)PHENOL 9&

Base Information

• Chemical Name: 4-(TERT-BUTYLDIMETHYLSILYLOXY)PHENOL 9&
• CAS No.: 108534-47-0
• Molecular Formula: C12H20O2Si
• Molecular Weight: 224.375
• Mol file: 108534-47-0.mol

Synonyms:4-(tert-Butyldimethylsiloxy)phenol;4-(tert-Butyldimethylsilanyloxy)phenol;4-((tert-Butyldimethylsilyl)oxy)phenol;

Chemical Property of 4-(TERT-BUTYLDIMETHYLSILYLOXY)PHENOL 9&

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 0.00526mmHg at 25°C
• Melting Point: 60-64 °C(lit.)
• Refractive Index: 1.49
• Boiling Point: 266.4 °C at 760 mmHg
• PKA: 10.24±0.15(Predicted)
• Flash Point: 114.9 °C
• PSA: 29.46000
• Density: 0.974 g/cm³
• LogP: 3.77620

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(tert-Butyldimethylsiloxy)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TERT-BUTYLDIMETHYLSILYLOXY)PHENOL 9&

There total 19 articles about 4-(TERT-BUTYLDIMETHYLSILYLOXY)PHENOL 9& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(4-allyloxy-phenoxy)-tert-butyl-dimethyl-silane → 4-(tert-butyldimethylsilyloxy)phenol (108534-47-0)

Guidance literature:

With magnesium; lithium tert-butoxide; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/ja039674a

Reference yield: 95.0%

4-Benzyloxyphenol (103-16-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(tert-butyldimethylsilyloxy)phenol (108534-47-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1039/c8cc04742a

Reference yield: 93.0%

[4-(Tetrahydropyran-2-yloxy)phenoxy]-tert-butyldimethylsilane (299917-31-0) → 4-(tert-butyldimethylsilyloxy)phenol (108534-47-0)

Guidance literature:

With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.0c00290

upstream raw materials:

4-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-cyclohexa-2,5-dienol

tert-butyldimethylsilyl chloride

hydroquinone

[4-(Adamantan-2-ylidene-phenyl-methoxy)-phenoxy]-tert-butyl-dimethyl-silane

Downstream raw materials:

2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-phenylsulfanyl]-isoindole-1,3-dione

3-(4-tert-butyldimethylsilyloxyphenoxy)-2-(S)-propyleneoxide

[4-(Tetrahydropyran-2-yloxy)phenoxy]-tert-butyldimethylsilane

(S)-1-[2-(4-Amino-phenyl)-ethylamino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenoxy]-propan-2-ol

Refernces

• 1、 Makawana, Dhaval,Singh, Man. "A new dendrimer series: synthesis, free radical scavenging and protein binding studies". . p. 21914 - 21932. Retrieved 2020.
• 2、 Poock, Caroline,Kalesse, Markus. "Total Synthesis and Structure Revision of Halioxepine". supporting information. p. 1615 - 1619. Retrieved 2020/12/23.
• 3、 Angelici, Gaetano,Carpita, Adriano,Casotti, Gianluca,Evangelisti, Claudio,Ferreri, Matteo,Fusini, Graziano,Pardini, Luca Fidia. "Total Synthesis of Asparenydiol by Two Sonogashira Cross-Coupling Reactions Promoted by Supported Pd and Cu Catalysts". . p. 1795 - 1803. Retrieved 2020/06/08.