5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine
• CAS No.: 1188525-51-0
• Molecular Formula: C₆H₁₅N*C₃₅H₃₃F₂N₅O₈
• Molecular Weight: 790.864
• Mol file: 1188525-51-0.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

succinic acid anhydride (108-30-5) + [5'-O-(4,4'-dimethoxytrityl)-2,2'-difluoro-2'-deoxyadenosin-3'-O-yl]-N,N-diisopropylaminocyanoethoxy phosphoramidite (1172578-46-9) + triethylamine (121-44-8) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine (1188525-51-0)

Guidance literature:

succinic acid anhydride; [5'-O-(4,4'-dimethoxytrityl)-2,2'-difluoro-2'-deoxyadenosin-3'-O-yl]-N,N-diisopropylaminocyanoethoxy phosphoramidite; With 2-(Dimethylamino)pyridine; In pyridine; at 20 ℃; for 6h; Inert atmosphere;

triethylamine; In methanol; dichloromethane;

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2,2'-difluoro-2'-deoxyadenosine (1172578-45-8) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine (1188525-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Ν,Ν-diisopropylamine tetrazonide / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: 2-(Dimethylamino)pyridine / pyridine / 6 h / 20 °C / Inert atmosphere

With 2-(Dimethylamino)pyridine; Ν,Ν-diisopropylamine tetrazonide; In pyridine; dichloromethane;

Reference yield:

2'-Deoxy-2,2'-difluoro-adenosine (147048-53-1) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl-2,2'-difluoro-2'-deoxy adenosine triethylamine (1188525-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 3 h / 20 °C

2: Ν,Ν-diisopropylamine tetrazonide / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: 2-(Dimethylamino)pyridine / pyridine / 6 h / 20 °C / Inert atmosphere

With 2-(Dimethylamino)pyridine; Ν,Ν-diisopropylamine tetrazonide; In pyridine; dichloromethane;

upstream raw materials:

succinic acid anhydride

[5'-O-(4,4'-dimethoxytrityl)-2,2'-difluoro-2'-deoxyadenosin-3'-O-yl]-N,N-diisopropylaminocyanoethoxy phosphoramidite

triethylamine

5'-O-(4,4'-dimethoxytrityl)-2,2'-difluoro-2'-deoxyadenosine

Refernces