Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI)

Base Information

• Chemical Name: Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI)
• CAS No.: 108321-66-0
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.596
• Mol file: 108321-66-0.mol

Synonyms:Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI)

Chemical Property of Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI)

There total 185 articles about Ethanone, 2-chloro-1-phenyl-, labeled with carbon-14 (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetophenone (98-86-2) → 2,2-dichloroacetophenone (2648-61-5) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In ethanol; at 91 - 93 ℃; for 0.25h; Further Variations:; Solvents; Temperatures; time; Product distribution;

DOI:10.1055/s-2004-834871

Reference yield: 73.0%

phenylacetylene (536-74-3) → 2,2-dichloroacetophenone (2648-61-5) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2)

Guidance literature:

With iodine; sodium chloride; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1039/c9cc00346k

Reference yield: 14.0%

dimethyl sulfoxide (67-68-5,8070-53-9) + phenylacetylene (536-74-3) → phenylglyoxal hydrate (1074-12-0) + 2,2-dichloroacetophenone (2648-61-5) + S-methyl 2-oxo-2-phenylethanethioate (13603-60-6) + 1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2)

Guidance literature:

With iodine; acetic acid; at 20 ℃; for 4h;

DOI:10.1039/c9cc00346k

upstream raw materials:

diazomethane

diethyl ether

benzoyl chloride

diethyl-(1,2-dichloro-vinyl)-amine

Downstream raw materials:

2-phenyl-2-(chloromethyl)oxirane

(3-furan-2-yl-oxiranyl)-phenyl-methanone

8-methyl-2-phenylimidazo[1,2-a]pyridine

4-phenyl-2-(2-pyridyl)thiazole

Refernces

• 1、 Kamigata, Nobumasa,Udodaira, Kumiko,Shimizu, Toshio. "Reactions of perfluoroalkanesulfonyl chlorides with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex". . p. 155 - 168. Retrieved 1997.
• 2、 El-Ahl, Abdel Aziz S.,Elbeheery, Akram H.,Amer, Fathy A.. "New, efficient synthesis of α-chloroketones using SiCl 4/urea-hydrogen peroxide or SiCl4/iodosylbenzene reagent systems". . p. 1508 - 1513. Retrieved 2011.
• 3、 Cousseau, Jack,Albert, Patrice. "Nucleophilic Fluorine Displacement Reactions. A Comparison of Reactivities of Polymer-Supported Fluoride and Acid Fluorides P+F-, nHF ( n = 0-2)". . p. 5380 - 5383. Retrieved 1989.
• 4、 Chen, Zheng-Wang,Ye, Dong-Nai,Ye, Min,Zhou, Zhong-Gao,Li, Shen-Huan,Liu, Liang-Xian. "AgF/TFA-promoted highly efficient synthesis of α-haloketones from haloalkynes". . p. 1373 - 1375. Retrieved 2014.
• 5、 Peppe, Clovis,Pav?o Das Chagas, Rafael. "Indium(I) bromide-mediated reductive coupling of α,α- dichloroketones to 1-aryl-butane-1,4-diones". . p. 1187 - 1190. Retrieved 2004.
• 6、 Bongini, Alessandro,Cainelli, Gianfranco,Contento, Michele,Manescalchi, Francesco. "Chlorination of Organic Compounds by Means of Polymer-supported Chlorine". . p. 1278 - 1279. Retrieved 1980.
• 7、 Hu, Sifan,Liu, Dayi,Yan, Chenyu,Cai, Mingzhong. "An efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes leading to α-halomethyl ketones". . p. 2983 - 2991. Retrieved 2018.
• 8、 Zhou, Zhong Shi,Li, Li,He, Xue Han. "A simple and convenient method for direct α-chlorination of ketones with ammonium chloride and Oxone". . p. 1213 - 1216,4. Retrieved 2012.
• 9、 Zheng, Zubiao,Han, Bingbing,Wu, Fang,Shi, Tengfei,Liu, Jie,Zhang, Yong,Hao, Jialong. "One-step for the preparation of α-haloacetal of ketones with N-bromosuccinimide/N-chlorosuccinimide (NBS/NCS) and ethylene glycol". . p. 7738 - 7743. Retrieved 2016.
• 10、 Sket,Zupet,Zupan,Dolenc. "α-Iodination of ketones and enol acetates with poly[styrene-co-(4-vinylpyridinium dichloroiodate(1-))]". . p. 3406 - 3408. Retrieved 1989.