5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT

Base Information

• Chemical Name: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT
• CAS No.: 108321-05-7
• Molecular Formula: C₅H₈O₁₄P₃*4Na
• Molecular Weight: 476.99
• Hs Code.: 29400090
• Mol file: 108321-05-7.mol

Synonyms:P-RIB-PP;P-RIB-PP, PRPP SODIUM SALT;ALPHA-D-RIBOSYLDIPHOSPHATE 5-PHOSPHATE SODIUM SALT;5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT;5-PHOSPHO-D-RIBOSE 1-DIPHOSPHATE SODIUM SALT;5-PHOSPHORYLRIBOSE 1-PYROPHOSPHATE SODIUM SALT;5-phosphorylribose 1-pyrophosphate*sodium;5-PHOSPHO-D-RIBOSE 1-DIPHOSPHAT

Chemical Property of 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT

Chemical Property:

• PSA: 270.49000
• LogP: -0.47850
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL, clear, colorless to very faintly yellow

Purity/Quality:

97% ^*data from raw suppliers

5-Phospho-D-ribose 1-diphosphate pentasodium salt ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-68/20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Phospho-D-ribose 1-Diphosphate is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism.

Technology Process of 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT

There total 3 articles about 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,β-D-ribofuranose-5-phophate disodium salt (108321-99-9,150713-51-2) → 5-phospho-D-ribosyl α-1-pyrophosphate (87372-47-2,94902-32-6,108321-05-7,129136-58-9)

Guidance literature:

With dipotassium hydrogenphosphate; edetate disodium; phospho(enol)pyruvic acid mono potassium salt; magnesium chloride; at 30 ℃; for 96h; immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4;

DOI:10.1021/ja00363a037

Reference yield:

adenosine-5'-monophosphate disodium salt (4578-31-8) → 5-phospho-D-ribosyl α-1-pyrophosphate (87372-47-2,94902-32-6,108321-05-7,129136-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Dowex 50 W-X₈ (H⁺ form) / H₂O / 0.14 h / Heating

2: 70 mmol / Na₂ATP, MgCl₂*6H₂O, PEP^-K⁺, K₂HPOu, Na₂EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4

With dipotassium hydrogenphosphate; Dowex 50 W-X₈ (H⁺ form); edetate disodium; phospho(enol)pyruvic acid mono potassium salt; magnesium chloride; In water;

DOI:10.1021/ja00363a037

Reference yield:

D-Ribose (532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7) → 5-phospho-D-ribosyl α-1-pyrophosphate (87372-47-2,94902-32-6,108321-05-7,129136-58-9)

Guidance literature:

With dipotassium hydrogenphosphate; DL-dithiothreitol; edetate disodium; phospho(enol)pyruvic acid mono potassium salt; magnesium chloride; for 72h; PAN-immobilized pyruvate kinase, adenylate kinase, PRPP synthetase, pH 7.5;

DOI:10.1021/ja00363a037

upstream raw materials:

D-Ribose

α,β-D-ribofuranose-5-phophate disodium salt

adenosine-5'-monophosphate disodium salt

Downstream raw materials:

disodium uridine-5'-monophosphate

Refernces