3-Pyridinamine,2,6-difluoro-(9CI)

Base Information

• Chemical Name: 3-Pyridinamine,2,6-difluoro-(9CI)
• CAS No.: 108118-69-0
• Molecular Formula: C5H4 F2 N2
• Molecular Weight: 130.1
• Hs Code.: 2933399090
• Mol file: 108118-69-0.mol

Synonyms:(2,6-Difluoropyridin-3-yl)amine;2,6-Difluoro-3-aminopyridine; 3-Amino-2,6-difluoropyridine

Chemical Property of 3-Pyridinamine,2,6-difluoro-(9CI)

Chemical Property:

• Boiling Point: 257.7±35.0 °C(Predicted)
• PKA: 1.24±0.10(Predicted)
• PSA: 38.91000
• Density: 1.393±0.06 g/cm3(Predicted)
• LogP: 1.52320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Difluoropyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinamine,2,6-difluoro-(9CI)

There total 3 articles about 3-Pyridinamine,2,6-difluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Difluoro-3-nitropyridine (58602-02-1) + iron (7439-89-6) → 2,6-difluoropyridin-3-ylamine (108118-69-0)

Guidance literature:

With ammonium chloride; In ethanol; water; ethyl acetate;

Reference yield:

2,6-Difluoro-3-nitropyridine (58602-02-1) → 2,6-difluoropyridin-3-ylamine (108118-69-0)

Guidance literature:

With iron; acetic acid; In ethanol; for 4h; Heating;

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 2,6-difluoropyridin-3-ylamine (108118-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / dimethylsulfone, KF / toluene / 1 h / 150 °C

2: iron, acetic acid / ethanol / 4 h / Heating

With potassium fluoride; dimethylsulfone; iron; acetic acid; In ethanol; toluene;

upstream raw materials:

2,6-Difluoro-3-nitropyridine

2,6-dicholoro-3-nitropyridine

iron

Downstream raw materials:

5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine

C₁₃H₁₀F₂N₂O₂

5-Fluoro-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-oxazolo[5,4-b]pyridine

C₂₁H₁₆F₂N₄O₂

Refernces

• 1、 Radl, Stanislav,Hradil, Pavel. "SYNTHESIS OF SOME 1-ALKYL-1,4-DIHYDRO-4-OXO-1,7-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS". . p. 2420 - 2429. Retrieved 2007/10/02.