Benzothiazole, 5-chloro-2-ethyl- (9CI)

Base Information

• Chemical Name: Benzothiazole, 5-chloro-2-ethyl- (9CI)
• CAS No.: 107611-11-0
• Molecular Formula: C₉H₈ClNS
• Molecular Weight: 197.688
• Mol file: 107611-11-0.mol

Synonyms:Benzothiazole, 5-chloro-2-ethyl- (9CI)

Chemical Property of Benzothiazole, 5-chloro-2-ethyl- (9CI)

Chemical Property:

• PSA: 41.13000
• LogP: 3.51210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 5-chloro-2-ethyl- (9CI)

There total 10 articles about Benzothiazole, 5-chloro-2-ethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-heptanedione (7424-54-6) + 4-chloro-2-aminobenzenethiol (1004-00-8) → 5-chloro-2-ethylbenzo[d]thiazole (107611-11-0)

Guidance literature:

With water; toluene-4-sulfonic acid; In acetonitrile; at 80 ℃; for 16h; Sealed tube;

DOI:10.1021/ol403475v

Reference yield: 79.8%

4-chloro-2-aminobenzenethiol (1004-00-8) + Triethyl orthopropionate (115-80-0) → 5-chloro-2-ethylbenzo[d]thiazole (107611-11-0)

Guidance literature:

at 90 ℃; for 6h;

Reference yield: 78.0%

N-methyl-N-phenylthiopropionamide (5310-08-7) + 4-chloro-2-aminobenzenethiol (1004-00-8) → 5-chloro-2-ethylbenzo[d]thiazole (107611-11-0)

Guidance literature:

With carbon tetrabromide; In neat (no solvent); at 70 ℃; for 26h; Green chemistry;

DOI:10.1039/c9ob02125f

upstream raw materials:

propionyl chloride

4-chloro-2-aminobenzenethiol

propionic acid anhydride

bis(2-nitro-4-chlorophenyl)disulfide

Refernces

• 1、 Zhong,Chen,Zhang. "Low-valent titanium induced simultaneous reduction of nitro group and S-S bond in nitrodisulfides: A novel method for the synthesis of benzothiazoline, benzothiazoles and 2,3-dihydro-1,5-benzothiazepines". . p. 4451 - 4460. Retrieved 2000.
• 2、 -. "Synthesis method of benzothiazole compound". Paragraph 0049-0053. . Retrieved 2021/07/14.
• 3、 Kazi, Imran,Sekar, Govindasamy. "An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst". . p. 9743 - 9756. Retrieved 2019/12/02.