3-Methylfuro[3,2-b]pyridine

Base Information

• Chemical Name: 3-Methylfuro[3,2-b]pyridine
• CAS No.: 107096-11-7
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20577825
• Nikkaji Number: J433.495G
• Wikidata: Q82467935
• Mol file: 107096-11-7.mol

Synonyms:3-Methylfuro[3,2-b]pyridine;107096-11-7;FURO[3,2-B]PYRIDINE,3-METHYL-(9CI);SCHEMBL7686600;DTXSID20577825

Chemical Property of 3-Methylfuro[3,2-b]pyridine

Chemical Property:

• PSA: 26.03000
• LogP: 2.13620
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.052763847
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

95% ^*data from raw suppliers

3-Methylfuro[3,2-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=COC2=C1N=CC=C2

Technology Process of 3-Methylfuro[3,2-b]pyridine

There total 8 articles about 3-Methylfuro[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methyl-furo[3,2-b]-pyridine-2-carboxylic acid (107096-09-3) → 3-methylfuro<3,2-b>pyridine (107096-11-7)

Guidance literature:

With copper; pyrolysis;

Reference yield: 15.0%

2-(3-furo<3,2-b>pyridyl)acetic acid (167420-49-7) → 3-methylfuro<3,2-b>pyridine (107096-11-7)

Guidance literature:

With copper; Heating;

DOI:10.1002/jhet.5570320122

Reference yield:

3-hydroxypyridine-2-carboxylic acid (874-24-8) → 3-methylfuro<3,2-b>pyridine (107096-11-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / sulfuric acid / benzene / 40 h / Heating

2: 83 percent / C₂H₅ONa / ethanol; CHCl₃ / 1) C₂H₅ONa, C₂H₅OH, 0 deg C, 30 min, 2) chloroform, room temperature, 15 h

3: 1) C₂H₅ONa 2) hydrochloric acid / 1) reflux, 14 h, 2) reflux, 3 h

4: 50 percent / 48percent aq. HBr / 19 h / Heating

5: 81 percent / K₂CO₃ / acetone / 2 h / Heating

6: 47 percent / C₂H₅ONa / toluene / 14 h / Heating

7: 90 percent / Cu powder / pyrolysis

With hydrogenchloride; sulfuric acid; hydrogen bromide; sodium ethanolate; copper; potassium carbonate; In ethanol; chloroform; acetone; toluene; benzene;

upstream raw materials:

3-methyl-furo[3,2-b]-pyridine-2-carboxylic acid

2-(3-furo<3,2-b>pyridyl)acetic acid

3-hydroxypyridine-2-carboxylic acid

ethyl 3-hydroxypyridine-2-carboxylate

Refernces

• 1、 Shiotani, Shunsaku,Morita, Hiroyuki. "Furopyridines.III.A New Synthesis of Furopyridine". . p. 665 - 668. Retrieved 2007/10/02.