(1-Aminocyclopropyl)methanol

Base Information

• Chemical Name: (1-Aminocyclopropyl)methanol
• CAS No.: 107017-72-1
• Molecular Formula: C4H9NO
• Molecular Weight: 87.1216
• Hs Code.: 29222990
• European Community (EC) Number: 815-997-5
• DSSTox Substance ID: DTXSID20556559
• Nikkaji Number: J1.413.017I
• Wikidata: Q72435500
• Mol file: 107017-72-1.mol

Synonyms:(1-Aminocyclopropyl)methanol;107017-72-1;1-Amino-cyclopropanemethanol;1-Aminocyclopropanemethanol;(1-Amino-cyclopropyl)-methanol;MFCD01318221;Cyclopropanemethanol, amino-;1-aminocyclopropanmethanol;1-amino-cyclopropanmethanol;1-Amino-cyaclopropanemethanol;(1-amino-cyclopropyl)methanol;1-Aminocyclopropane-1-methanol;AMY5592;DTXSID20556559;OBMKZINZPBARIK-UHFFFAOYSA-N;(1-hydroxymethyl-cyclopropyl)-amine;1-Amino-1-hydroxymethylcyclopropane;AKOS006344998;AC-1482;PB26047;PS-17358;SY047102;EN300-107702;J-500114

Chemical Property of (1-Aminocyclopropyl)methanol

Chemical Property:

• Vapor Pressure: 2.168mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 143.236 °C at 760 mmHg
• PKA: 15.10±0.10(Predicted)
• Flash Point: 40.428 °C
• PSA: 46.25000
• Density: 1.12 g/cm³
• LogP: 0.17030
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 58.6

Purity/Quality:

99% ^*data from raw suppliers

(1-Aminocyclopropyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(CO)N

Technology Process of (1-Aminocyclopropyl)methanol

There total 5 articles about (1-Aminocyclopropyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

aminocyclopropane-1-carboxylic acid (22059-21-8) → 1-(hydroxymethyl)cyclopropylamine (107017-72-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 18h; Reflux; Inert atmosphere;

DOI:10.1055/s-0037-1611670

Reference yield: 98.0%

ethyl 1-aminocyclopropanecarboxylate hydrochloride (42303-42-4) → 1-(hydroxymethyl)cyclopropylamine (107017-72-1)

Guidance literature:

ethyl 1-aminocyclopropanecarboxylate hydrochloride; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

With water; sodium sulfate; In tetrahydrofuran; for 2h;

Reference yield: 95.0%

ethyl 1-aminocyclopropane-1-carboxylate hydrochloride → 1-(hydroxymethyl)cyclopropylamine (107017-72-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

upstream raw materials:

aminocyclopropane-1-carboxylic acid

ethyl 1-aminocyclopropanecarboxylate hydrochloride

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate

ethyl 1-aminocyclopropane-1-carboxylate

Downstream raw materials:

3-[4-(1-hydroxymethyl-cyclopropylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

ethyl 2,3,4,5-tetrafluoro-α-<<<1-(hydroxymethyl)cyclopropyl>amino>methylene>-β-oxobenzenepropanoate

Refernces

• 1、 Chessari, Gianni,Hardcastle, Ian R.,Ahn, Jong Sook,Anil, Burcu,Anscombe, Elizabeth,Bawn, Ruth H.,Bevan, Luke D.,Blackburn, Timothy J.,Buck, Ildiko,Cano, Celine,Carbain, Benoit,Castro, Juan,Cons, Ben,Cully, Sarah J.,Endicott, Jane A.,Fazal, Lynsey,Golding, Bernard T.,Griffin, Roger J.,Haggerty, Karen,Harnor, Suzannah J.,Hearn, Keisha,Hobson, Stephen,Holvey, Rhian S.,Howard, Steven,Jennings, Claire E.,Johnson, Christopher N.,Lunec, John,Miller, Duncan C.,Newell, David R.,Noble, Martin E. M.,Reeks, Judith,Revill, Charlotte H.,Riedinger, Christiane,St. Denis, Jeffrey D.,Tamanini, Emiliano,Thomas, Huw,Thompson, Neil T.,Vinkovi?, Mladen,Wedge, Stephen R.,Williams, Pamela A.,Wilsher, Nicola E.,Zhang, Bian,Zhao, Yan. "Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction". . p. 4071 - 4088. Retrieved 2021.
• 2、 -. "NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE". Paragraph 0368. . Retrieved 2019/01/17.