1-Boc-amino-3,6,9-trioxaundecanyl-11-ol

Base Information

• Chemical Name: 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
• CAS No.: 106984-09-2
• Molecular Formula: C13H27NO6
• Molecular Weight: 293.36
• Hs Code.: 2924199090
• European Community (EC) Number: 854-726-5
• DSSTox Substance ID: DTXSID00450208
• Wikidata: Q82269817
• Mol file: 106984-09-2.mol

Synonyms:106984-09-2;1-Boc-amino-3,6,9-trioxaundecanyl-11-ol;N-Boc-PEG4-alcohol;tert-Butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate;BocNH-PEG4-OH;t-boc-N-amido-PEG4-alcohol;N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL;NHBoc-PEG4-OH;Boc-NH-PEG4;Tert-butyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate;2-[2-(2-(2-Boc-aminoethoxy)ethoxy)ethoxy]ethanol;MFCD07779195;N-Boc-aminoethoxy-ethoxy-ethoxy-ethanol;2-[2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethoxy]ethanol;Boc-NH-PEG4-OH;tert-butyl N-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl)carbamate;SCHEMBL10491984;DTXSID00450208;XKKDQIAPTPFIGW-UHFFFAOYSA-N;BCP30521;EX-A3891;tert-Butyl 2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethyl carbamate;tert-Butyl 2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethylcarbamate;AKOS015909234;DS-3295;HY-W025896;(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-carbamic Acid tert-Butyl Ester;BP-21099;SY059539;CS-0067500;FT-0663467;H10213;EN300-6493675;A911265;J-001685;tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethylcarbamate;2-(2-(2-(2-(T-BUTYLOXYCARBONYLAMINO)ETHOXY)ETHOXY)ETHOXY)ETHANOL;T-BUTYL-2-(2-(2-(2-HYDROXYETHOXY)ETHOXY)ETHOXY)ETHYLCARBAMATE;1-Boc-amino-3,6,9-trioxaundecanyl-11-ol pound>>N-Boc-PEG4-alcohol pound>>BocNH-PEG4-OH

Chemical Property of 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol

Chemical Property:

• Appearance/Colour: Yellow Oil
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.459
• Boiling Point: 414 °C at 760mmHg
• PKA: 12.23±0.46(Predicted)
• Flash Point: 204.2 °C
• PSA: 86.25000
• Density: 1.078 g/cm³
• LogP: 0.94410
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 13
• Exact Mass: 293.18383758
• Heavy Atom Count: 20
• Complexity: 242

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Boc-amino-3,6,9-trioxaundecanyl-11-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCO
• Uses: 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol is a compound useful in organic synthesis.
• Description: N-Boc-PEG4-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol

There total 16 articles about 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + 11-amino-3,6,9-trioxaundecanol (86770-74-3) → 2-<2-<2-<2-<(tert-Butoxycarbonyl)amino>ethoxy>ethoxy>ethoxy>ethanol (106984-09-2)

Guidance literature:

With triethylamine; In methanol; Reflux;

DOI:10.1039/c9cc02882j

Reference yield: 90.0%

→ 2-<2-<2-<2-<(tert-Butoxycarbonyl)amino>ethoxy>ethoxy>ethoxy>ethanol (106984-09-2)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 520 ℃; for 0.0833333h;

With di-tert-butyl dicarbonate; water; In tetrahydrofuran; at 20 ℃; for 71h;

Reference yield: 86.0%

tert-butyldicarbonate (34619-03-9) + 11-amino-3,6,9-trioxaundecanol (86770-74-3) → 2-<2-<2-<2-<(tert-Butoxycarbonyl)amino>ethoxy>ethoxy>ethoxy>ethanol (106984-09-2)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2011.03.144

upstream raw materials:

di-tert-butyl dicarbonate

11-amino-3,6,9-trioxaundecanol

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

Tetraethylene glycol

Downstream raw materials:

(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid

[2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid

C₄₂H₇₈NO₁₉P

C₃₇H₇₀NO₁₇P

Refernces

• 1、 Zhang, Xiaocui,Wu, Xueting,Jiang, Shichao,Gao, Jingshuo,Yao, Zhuojun,Deng, Jiajie,Zhang, Linmeng,Yu, Zhipeng. "Photo-accelerated "click" reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation". . p. 7187 - 7190. Retrieved 2019.
• 2、 Casiraghi, Andrea,Longhena, Francesca,Straniero, Valentina,Faustini, Gaia,Newman, Amy H.,Bellucci, Arianna,Valoti, Ermanno. "Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET-Based Assay of Synapsin III Binding". . p. 1330 - 1337. Retrieved 2020.
• 3、 Chudasama, Vijay,Kuan, Seah Ling,Nogueira, Jo?o C. F.,Raabe, Marco,Weil, Tanja,Xu, Lujuan,Zegota, Maksymilian M.. "Site-selective protein modification: Via disulfide rebridging for fast tetrazine/ trans -cyclooctene bioconjugation". . p. 1140 - 1147. Retrieved 2020.
• 4、 -. "IRAK DEGRADERS AND USES THEREOF". Paragraph 00962; 001046-001048. . Retrieved 2020/06/19.