Technology Process of 6-benzyloxy-7-methoxy-2-methyl-N-(tert-butyl)quinoline-3-carboxamide
There total 6 articles about 6-benzyloxy-7-methoxy-2-methyl-N-(tert-butyl)quinoline-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-benzyloxy-7-methoxy-2-methylquinoline-3-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
tert-butylamine;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
DOI:10.3390/molecules17055497
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
2.1: nitric acid / 2 h / 0 - 20 °C
3.1: ammonium chloride; zinc / ethanol; water / 2 h / 20 °C
4.1: toluene-4-sulfonic acid / 0.17 h / 100 °C
4.2: 5 h / Reflux
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C
5.2: 5 h / 20 °C
With
nitric acid; potassium carbonate; ammonium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc;
In
ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules17055497
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 0.17 h / 100 °C
1.2: 5 h / Reflux
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 5 h / 20 °C
With
benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
DOI:10.3390/molecules17055497