3,4-dichlorobenzoyl formic acid

Base Information

• Chemical Name: 3,4-dichlorobenzoyl formic acid
• CAS No.: 64471-83-6
• Molecular Formula: C₈H₄Cl₂O₃
• Molecular Weight: 219.024
• Mol file: 64471-83-6.mol

Synonyms:3,4-dichlorobenzoyl formic acid

Chemical Property of 3,4-dichlorobenzoyl formic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dichlorobenzoyl formic acid

There total 2 articles about 3,4-dichlorobenzoyl formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 3,4-dichlorobenzoyl formic acid (64471-83-6)

Guidance literature:

With hydrogenchloride; sodium dichromate; In water; at 95 ℃; for 6h;

Reference yield:

3',4'-dichloroacetophenone (2642-63-9) → 3,4-dichlorobenzoyl formic acid (64471-83-6)

Guidance literature:

With selenium(IV) oxide;

DOI:10.1002/chem.201402516

Reference yield: 95.0%

benzoxazole (273-53-0,29791-96-6) + 3,4-dichlorobenzoyl formic acid (64471-83-6) → benzo[d]oxazol-2-yl(3,4-dichlorophenyl)methanone (1613144-29-8)

Guidance literature:

With nickel(II) perchlorate hexahydrate; silver carbonate; In benzene; at 170 ℃; for 24h;

DOI:10.1002/chem.201402516

upstream raw materials:

3',4'-dichloroacetophenone

Downstream raw materials:

5-(3,4-Dichloro-phenyl)-6-hydroxy-pyrazine-2,3-dicarbonitrile

5-chloro-6-(3,4-dichloro-phenyl)-pyrazine-2,3-dicarbonitrile

5-(3,4-dichloro-phenyl)-6-ethylamino-pyrazine-2,3-dicarbonitrile

benzo[d]oxazol-2-yl(3,4-dichlorophenyl)methanone

Refernces

• 1、 Oboh, Edmund,Schubert, Tanner J.,Teixeira, Jose E.,Stebbins, Erin E.,Miller, Peter,Philo, Emily,Thakellapalli, Haresh,Campbell, Scott D.,Griggs, David W.,Huston, Christopher D.,Meyers, Marvin J.. "Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin". . p. 11729 - 11745. Retrieved 2021/08/24.
• 2、 Xie, Jianing,Xue, Sijing,Escudero-Adán, Eduardo C.,Kleij, Arjan W.. "Domino Synthesis of α,β-Unsaturated γ-Lactams by Stereoselective Amination of α-Tertiary Allylic Alcohols". supporting information. p. 16727 - 16731. Retrieved 2018/11/23.