Technology Process of 7-(bicyclo[3.1.0]hexan-6-ylmethoxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine
There total 8 articles about 7-(bicyclo[3.1.0]hexan-6-ylmethoxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: acetic acid / 2-methoxy-ethanol / Reflux
2: nitric acid; sulfuric acid
3: thionyl chloride
4: isopropyl alcohol
5: potassium carbonate / 1,4-dioxane / 24 h / 20 °C / Inert atmosphere
6: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
With
thionyl chloride; sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; potassium carbonate; acetic acid;
In
tetrahydrofuran; 1,4-dioxane; 2-methoxy-ethanol; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: nitric acid; sulfuric acid
2: thionyl chloride
3: isopropyl alcohol
4: potassium carbonate / 1,4-dioxane / 24 h / 20 °C / Inert atmosphere
5: palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
With
thionyl chloride; sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;