3-Hydroxy-3-phenylpropionyl azide

Base Information

• Chemical Name: 3-Hydroxy-3-phenylpropionyl azide
• CAS No.: 103126-26-7
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.189
• Mol file: 103126-26-7.mol

Synonyms:3-Hydroxy-3-phenylpropionyl azide

Chemical Property of 3-Hydroxy-3-phenylpropionyl azide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Hydroxy-3-phenylpropionyl azide

There total 3 articles about 3-Hydroxy-3-phenylpropionyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-3-hydroxypropionic acid hydrazide (86217-47-2) → 3-Hydroxy-3-phenylpropionyl azide (103126-26-7)

Guidance literature:

With hydrogenchloride; sodium nitrite;

Reference yield:

Ethyl 3-hydroxy-3-phenylpropanoate (5764-85-2) → 3-Hydroxy-3-phenylpropionyl azide (103126-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 85percent Hydrazine hydrate / ethanol / 0.5 h / Ambient temperature

2: NaNO₂, 3 N HCl / H₂O / -10 - -3 °C

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In ethanol; water;

DOI:10.1021/jo00163a019

Reference yield:

3-bromo-3-phenylpropionic acid (15463-91-9) → 3-Hydroxy-3-phenylpropionyl azide (103126-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: absolute alcohol; hydrazine hydrate

2: hydrochloric acid; sodium nitrite

With hydrogenchloride; ethanol; hydrazine hydrate; sodium nitrite;

upstream raw materials:

3-phenyl-3-hydroxypropionic acid hydrazide

Ethyl 3-hydroxy-3-phenylpropanoate

3-bromo-3-phenylpropionic acid

Downstream raw materials:

N-<(R)-1-(1-Naphthyl)ethyl>-(5S)-phenyl-2-oxazolidone-3-carboxamide

N-<(R)-1-(1-Naphthyl)ethyl>-(5R)-phenyl-2-oxazolidone-3-carboxamide

3-hydroxy-N,3-diphenylpropanamide

5-phenyloxazolidin-2-one

Refernces