dibenzyl (R)-2-hydroxysuccinate

Base Information

• Chemical Name: dibenzyl (R)-2-hydroxysuccinate
• CAS No.: 99266-22-5
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.338
• Mol file: 99266-22-5.mol

Synonyms:dibenzyl (R)-2-hydroxysuccinate

Chemical Property of dibenzyl (R)-2-hydroxysuccinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl (R)-2-hydroxysuccinate

There total 1 articles about dibenzyl (R)-2-hydroxysuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

D-Malic acid (636-61-3,78644-42-5) + benzyl alcohol (100-51-6,185532-71-2) → dibenzyl (R)-2-hydroxysuccinate (99266-22-5)

Guidance literature:

With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt;

DOI:10.1016/S0040-4039(00)88555-X

Reference yield: 70.0%

dibenzyl (R)-2-hydroxysuccinate (99266-22-5) → (3R)-3,4-dihydroxybutyric acid benzyl ester (133039-03-9)

Guidance literature:

With sodium tetrahydroborate; dimethylsulfide borane complex;

DOI:10.1016/S0040-4039(00)88555-X

Reference yield:

C16H15ClN2O4 + dibenzyl (R)-2-hydroxysuccinate (99266-22-5) → C34H32N2O9

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 0.416667h;

upstream raw materials:

D-Malic acid

benzyl alcohol

Downstream raw materials:

(3R)-3,4-dihydroxybutyric acid benzyl ester

dibenzyl (2S,3R)-2-benzyl-3-hydroxysuccinate

benzyl (2S,3R)-2-benzyl-3,4-epoxybutanoate

benzyl (2R,3S)-2-benzyl-3,4-epoxybutanoate

Refernces

• 1、 Lee, Soo Suk,Li, Zhi-Hong,Lee, Dong Ha,Kim, Dong H.. "(2R,3S)- and (2S,3R)-2-benzyl-3,4-epoxybutanoic acid as highly efficient and fast acting pseudomechanism-based inactivators for carboxypeptidase A: design, asymmetric synthesis and inhibitory kinetics". . p. 2877 - 2882. Retrieved 2007/10/02.