Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 %

Base Information

• Chemical Name: Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 %
• CAS No.: 104227-38-5
• Molecular Formula: C9H17 O6 P
• Molecular Weight: 252.204
• Hs Code.: 2920909090
• Mol file: 104227-38-5.mol

Synonyms:Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 %

Chemical Property of Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 %

Chemical Property:

• PSA: 88.71000
• LogP: 1.38470

Purity/Quality:

99% ^*data from raw suppliers

DIMETHYL-5-MEHTOXYCARBONYL-2-OXOPENTYL PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 %

There total 12 articles about Dimethyl-5-mehtoxycarbonyl-2-oxopentyl phosphonate, 98 % which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-methylpentafluorophenyl pentanedioate (904691-68-5) + dimethyl α-trimethylsilylmethylphosphonate (13433-42-6) → methyl 6-(dimethoxyphosphoryl)-5-oxohexanoate (104227-38-5)

Guidance literature:

dimethyl α-trimethylsilylmethylphosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-methylpentafluorophenyl pentanedioate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; chemoselective reaction;

DOI:10.1021/acs.joc.5b00039

Reference yield: 95.0%

methanol (67-56-1) + dimethyl 2-oxo-5-(carbo-tert-butoxy)pentanephosphonate (87517-46-2) → methyl 6-(dimethoxyphosphoryl)-5-oxohexanoate (104227-38-5)

Guidance literature:

With trifluoroacetic acid; for 10h; Heating;

DOI:10.1021/jo00312a031

Reference yield: 45.0%

1-methylpentafluorophenyl pentanedioate (904691-68-5) + dimethyl methane phosphonate (756-79-6) → methyl 6-(dimethoxyphosphoryl)-5-oxohexanoate (104227-38-5)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-methylpentafluorophenyl pentanedioate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

DOI:10.1021/acs.joc.5b00039

upstream raw materials:

methanol

dimethyl 2-oxo-5-(carbo-tert-butoxy)pentanephosphonate

diazomethane

glutaric anhydride,

Downstream raw materials:

(E)-5-Oxo-7-phenyl-hept-6-enoic acid methyl ester

Benzoic acid (1S,2R,3R,4R)-3-((E)-6-methoxycarbonyl-3-oxo-hex-1-enyl)-2-((Z)-oct-2-enyl)-4-(tetrahydro-pyran-2-yloxy)-cyclopentyl ester

Refernces

• 1、 Gore, Vivek,Patel, Pranav,Chang, Chih-Tsung,Sivendran, Sashikala,Kang, Namin,Ouedraogo, Yannick P.,Gravel, Sylvie,Powell, William S.,Rokach, Joshua. "5-Oxo-ETE receptor antagonists". . p. 3725 - 3732. Retrieved 2013.
• 2、 Miftakhov,Imaeva,Fatykhov,Akhmetvaleev. "Prostanoids: LXVI. A priori Postulated "9-LO Prostanoids"". . p. 47 - 54. Retrieved 2007/10/03.