Technology Process of (E)-dimethyl 2,5-dibenzylhex-2-enedioate
There total 3 articles about (E)-dimethyl 2,5-dibenzylhex-2-enedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,4-triphenyl-4H-1,2,4-triazol-1-ium perchlorate;
In
1,4-dioxane;
at 80 ℃;
for 24h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201103555
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 6 h / 20 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,4-triphenyl-4H-1,2,4-triazol-1-ium perchlorate / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere
With
1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,4-triphenyl-4H-1,2,4-triazol-1-ium perchlorate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/anie.201103555
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 0 °C / Inert atmosphere
1.2: 12 h / 70 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 6 h / 20 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,4-triphenyl-4H-1,2,4-triazol-1-ium perchlorate / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere
With
potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3,4-triphenyl-4H-1,2,4-triazol-1-ium perchlorate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; tert-butyl alcohol;
DOI:10.1002/anie.201103555
