(R )-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (R )-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester
• CAS No.: 130406-35-8
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• Mol file: 130406-35-8.mol

Synonyms:N^β-<(benzyloxy)carbonyl>-(R)-β-amino-2-phenylethanamine

Chemical Property of (R )-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

(R)-(2-AMINO-1-PHENYL-ETHYL)-CARBAMIC ACID BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R )-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester

There total 5 articles about (R )-(2-Amino-1-phenyl-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(benzyloxy)carbonyl]-(R)-β-amino-1-azido-2-phenylethane (130406-38-1) → Nβ-<(benzyloxy)carbonyl>-(R)-β-amino-2-phenylethanamine (130406-35-8,142854-51-1)

Guidance literature:

With Lindlar's catalyst; hydrogen; In ethyl acetate; at 30 ℃; for 6h; under 2327.2 Torr;

DOI:10.1021/jm00105a062

Reference yield:

D-2-phenylglycinol (56613-80-0) → Nβ-<(benzyloxy)carbonyl>-(R)-β-amino-2-phenylethanamine (130406-35-8,142854-51-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / Et₃N / tetrahydrofuran / 18 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: NaN₃ / dimethylformamide / 3 h / 80 °C

4: Lindlar catalyst, H₂ / ethyl acetate / 6 h / 30 °C / 2327.2 Torr

With Lindlar's catalyst; sodium azide; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00105a062

Reference yield:

(R)-benzyl [2-hydroxy-1-phenylethyl]carbamate (120666-53-7) → Nβ-<(benzyloxy)carbonyl>-(R)-β-amino-2-phenylethanamine (130406-35-8,142854-51-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: Lindlar catalyst, H₂ / ethyl acetate / 6 h / 30 °C / 2327.2 Torr

With Lindlar's catalyst; sodium azide; hydrogen; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00105a062

upstream raw materials:

N-[(benzyloxy)carbonyl]-(R)-β-amino-1-azido-2-phenylethane

D-2-phenylglycinol

(R)-benzyl [2-hydroxy-1-phenylethyl]carbamate

toluene-4-sulfonic acid (R)-2-benzyloxycarbonylamino-2-phenyl-ethyl ester

Downstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl *,R^*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diphenyl-10-oxa-2,5,8-triazaundecanoate

[(S)-1-((R)-2-Benzyloxycarbonylamino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester

[(S)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester

tricyclo<3.3.1.1^3,7>dec-2-yl *,R^*)>-<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>carbamate

Refernces