N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester

Base Information

• Chemical Name: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester
• CAS No.: 256478-25-8
• Molecular Formula: C₂₃H₂₆ClN₅O₄S
• Molecular Weight: 504.01
• Mol file: 256478-25-8.mol

Synonyms:N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester

Chemical Property of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester

There total 12 articles about N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (256477-34-6) + CH2Cl2-MeOH-0.880NH3 + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (256478-25-8) + N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine trifluoroacetate

Guidance literature:

With NaH; In 1,2-dimethoxyethane; mineral oil;

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (256477-34-6) + N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine trifluoroacetate + CH2 Cl2 -MeOH-0.880NH3 + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (256478-25-8)

Guidance literature:

With NaH; In 1,2-dimethoxyethane; mineral oil;

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester (256477-34-6) + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-benzylglycine tert-butyl ester (256478-25-8)

Guidance literature:

guanidine hydrochloride; With sodium hydride; In 1,2-dimethoxyethane; at 60 ℃; for 0.5h;

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester; In 1,2-dimethoxyethane; at 90 ℃; for 18h; Further stages.;

DOI:10.1021/jm061066t

upstream raw materials:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-benzylglycine t-butyl ester

guanidine hydrochloride

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

1,4-dichloro-7-isoquinolinesulphonyl chloride

Refernces

• 1、 -. "Composition for the treatment of damaged tissue". . . Retrieved 2008/06/13.
• 2、 -. "Isoquinolines". . . Retrieved 2008/06/13.