Technology Process of (2S,3S)-1,11-bis-tert-butyldiphenylsilyloxy-2,3-epoxy-5-undecyne
There total 9 articles about (2S,3S)-1,11-bis-tert-butyldiphenylsilyloxy-2,3-epoxy-5-undecyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / imidazole, pyridine / 0.5 h / 20 °C
2: 99 percent / CuI, NaI, K2CO3 / dimethylformamide / 20 h / 20 °C
3: 30 percent / LiAlH4 / diethyl ether / 3 h / Heating
4: ButOOH, Ti(OPri)4, 4 A molecular sieves, diethyl L-(+)-tartrate / CH2Cl2 / 72 h / -20 °C
5: 55 percent / Bu4NF / tetrahydrofuran / 1 h / 20 °C
6: 94 percent / imidazole / dimethylformamide / 1 h / 60 °C
With
pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; sodium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: dimethylsulfoxide / 2 h
2: SOCl2 / 3 h / Heating
3: 91 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
4: 99 percent / imidazole, pyridine / 0.5 h / 20 °C
5: 99 percent / CuI, NaI, K2CO3 / dimethylformamide / 20 h / 20 °C
6: 30 percent / LiAlH4 / diethyl ether / 3 h / Heating
7: ButOOH, Ti(OPri)4, 4 A molecular sieves, diethyl L-(+)-tartrate / CH2Cl2 / 72 h / -20 °C
8: 55 percent / Bu4NF / tetrahydrofuran / 1 h / 20 °C
9: 94 percent / imidazole / dimethylformamide / 1 h / 60 °C
With
pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; lithium aluminium tetrahydride; thionyl chloride; diethyl (2R,3R)-tartrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; potassium carbonate; sodium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;