Technology Process of 6-(2,3-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one
There total 11 articles about 6-(2,3-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 81.6 percent / N-bromosuccinimide / CCl4 / 5 h / Heating; Irradiation
2: 57.7 percent / methanol / 5 h / Heating
3: 100 percent / NaOH / methanol / 0.5 h / Heating
4: 91.5 percent / manganese dioxide / CH2Cl2 / 3 h / Ambient temperature
5: p-TsOH / 1.) THF, reflux, 2 h, 2.)THF, water, reflux, 1 h
6: 74.5 percent / KOH / tetrahydrofuran; ethanol / 4 h / Ambient temperature
7: 91 percent / 75percent aq. AcOH / 1 h / 100 °C
8: 96 percent / conc.H2SO4 / 2 h
9: H2SO4, sodium nitrite / H2O; acetonitrile / 4 h / 50 °C
10: 85 percent / hydrazine hydrate / ethanol / 2 h / Heating
11: 80 percent / H2 / Raney Ni / methanol / Ambient temperature
With
manganese(IV) oxide; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; sodium nitrite;
nickel;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/0223-5234(93)90006-Z
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 57.7 percent / methanol / 5 h / Heating
2: 100 percent / NaOH / methanol / 0.5 h / Heating
3: 91.5 percent / manganese dioxide / CH2Cl2 / 3 h / Ambient temperature
4: p-TsOH / 1.) THF, reflux, 2 h, 2.)THF, water, reflux, 1 h
5: 74.5 percent / KOH / tetrahydrofuran; ethanol / 4 h / Ambient temperature
6: 91 percent / 75percent aq. AcOH / 1 h / 100 °C
7: 96 percent / conc.H2SO4 / 2 h
8: H2SO4, sodium nitrite / H2O; acetonitrile / 4 h / 50 °C
9: 85 percent / hydrazine hydrate / ethanol / 2 h / Heating
10: 80 percent / H2 / Raney Ni / methanol / Ambient temperature
With
manganese(IV) oxide; potassium hydroxide; sodium hydroxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; sodium nitrite;
nickel;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/0223-5234(93)90006-Z