3-Oxo Ropinirole (Ropinirole Impurity C)

Base Information

• Chemical Name: 3-Oxo Ropinirole (Ropinirole Impurity C)
• CAS No.: 102842-51-3
• Molecular Formula: C16H22 N2 O2
• Molecular Weight: 274.36
• Hs Code.: 2933990090
• Mol file: 102842-51-3.mol

Synonyms:4-[2-(Dipropylamino)ethyl]isatin;SKF 96266

Chemical Property of 3-Oxo Ropinirole (Ropinirole Impurity C)

Chemical Property:

• PKA: 9.72±0.20(Predicted)
• PSA: 49.41000
• Density: 1.112
• LogP: 2.62390
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-(Dipropylamino)ethyl)indoline-2,3-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Oxo Ropinirole (Ropinirole Impurity C) is a related impurity of Ropinirole, potentially formed during its synthesis. Useful as antihypertensives and antianginal agents. Ropinirole impuriy C 3-Oxo Ropinirole is an impurity of Ropinirole. Ropinirole is a potent anti-Parkinson''s disease drug developed by SmithKline Beecham Pharmaceuticals.

Technology Process of 3-Oxo Ropinirole (Ropinirole Impurity C)

There total 1 articles about 3-Oxo Ropinirole (Ropinirole Impurity C) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ropinirole hydrochloride (91374-20-8) → 4-(2-dipropylaminoethyl)-1-hydroxy-1,3-dihydroindol-2-one (954117-22-7) + 4-(2-dipropylaminoethyl)-1H-indol-2,3-dione (102842-51-3) + 2-nitro-6-<2-(di-n-propylamino)ethyl>phenylacetic acid (720656-64-4)

Guidance literature:

With dihydrogen peroxide; In dihydrogen peroxide; at 80 ℃; for 5h;

DOI:10.1002/jccs.201000052

upstream raw materials:

ropinirole hydrochloride

Refernces