4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

Base Information

• Chemical Name: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
• CAS No.: 960356-44-9
• Molecular Formula: C₃₃H₃₀N₄O₂*H₃N
• Molecular Weight: 531.657
• Mol file: 960356-44-9.mol

Synonyms:4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

Chemical Property of 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt

There total 5 articles about 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

telmisatran (144701-48-4) → 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt (960356-44-9)

Guidance literature:

With ammonia; In ethanol; at 10 - 15 ℃; Solvent; Temperature; Large scale;

Reference yield: 95.1%

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester (528560-93-2) → 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt (960356-44-9)

Guidance literature:

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester; With sodium hydroxide; In methanol; water; at 80 ℃; for 3h;

With ammonium hydroxide; In ethanol; water; ethyl acetate; at 25 ℃; for 3h; Temperature;

Reference yield:

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9) → 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt (960356-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / isopropyl alcohol; dimethyl sulfoxide / 1 h / 45 °C

1.2: 6 h / 30 °C

2.1: sodium hydroxide / methanol; water / 3 h / 80 °C

2.2: 3 h / 25 °C

With potassium tert-butylate; sodium hydroxide; In methanol; water; dimethyl sulfoxide; isopropyl alcohol;

upstream raw materials:

telmisatran

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

Methyl 4'-(bromomethyl)biphenyl-2-carboxylate

4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester

Downstream raw materials:

telmisatran

Refernces

• 1、 -. "Telmisartan ammonium salt crystal form and preparation method thereof". Paragraph 0039; 0040. . Retrieved 2016/10/10.
• 2、 -. "PREPARATION OF TELMISARTAN SALTS". Page/Page column 36-37. . Retrieved 2008/06/13.