neomenthyl chloride

Base Information

• Chemical Name: neomenthyl chloride
• CAS No.: 13371-12-5
• Molecular Formula: C₁₀H₁₉Cl
• Molecular Weight: 174.714
• Mol file: 13371-12-5.mol

Synonyms:neomenthyl chloride

Chemical Property of neomenthyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of neomenthyl chloride

There total 17 articles about neomenthyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1S,2R,5S)-(+)-menthol (15356-60-2) → (+)-(1S,2S,5R)-menthyl chloride (13371-12-5,16052-42-9,26348-39-0,28953-96-0,29707-60-6,80483-49-4,80483-50-7,104012-59-1,65494-15-7)

Guidance literature:

With Me₂SeCl₂; triphenylphosphine; In benzene; for 24h; Ambient temperature;

DOI:10.1021/jo981324x

Reference yield: 85.0%

(-)-menthol (2216-51-5) → neomenthyl chloride (13371-12-5)

Guidance literature:

With tetrachloromethane; triphenylphosphine; at 24 ℃; Heating;

DOI:10.1002/ejoc.200600044

Reference yield: 83.0%

(-)-menthol (2216-51-5) → (+)-(1S,2S,5R)-menthyl chloride (13371-12-5,16052-42-9,26348-39-0,28953-96-0,29707-60-6,80483-49-4,80483-50-7,104012-59-1,65494-15-7)

Guidance literature:

With triphenylphosphine; In tetrachloromethane; toluene; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1039/c2ob07074j

upstream raw materials:

(-)-menthol

2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran

(1S,2S,4R)-2-bromo-1-isopropyl-4-methylcyclohexane

C₂₂H₃₄O₇S

Downstream raw materials:

3-p-menthene

{1R-(1α,2β,5α)}-diphenylmenthylphosphine

Menthan

Menthan

Refernces

• 1、 Su, Justin Y.,Grünenfelder, Denise C.,Takeuchi, Kohei,Reisman, Sarah E.. "Radical Deoxychlorination of Cesium Oxalates for the Synthesis of Alkyl Chlorides". . p. 4912 - 4916. Retrieved 2018.
• 2、 Silva-Cuevas, Carolina,Perez-Arrieta, Carlos,Polindara-García, Luis A.,Lujan-Montelongo, J. Armando. "Sulfonyl halide synthesis by thiol oxyhalogenation using NBS/NCS – iPrOH". . p. 2244 - 2247. Retrieved 2017/05/16.