1-(4'-ethylphenyl)-2,2,2-trifluoroethanol

Base Information

• Chemical Name: 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol
• CAS No.: 131252-25-0
• Molecular Formula: C₁₀H₁₁F₃O
• Molecular Weight: 204.192
• Mol file: 131252-25-0.mol

Synonyms:1-(4'-ethylphenyl)-2,2,2-trifluoroethanol

Chemical Property of 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol

There total 4 articles about 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(trifluoromethylsulfonyl)benzene (426-58-4) + 4-ethylbenzylaldehyde (4748-78-1) → 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol (131252-25-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at -50 - 20 ℃;

DOI:10.1021/ol035045u

Reference yield: 83.0%

→ 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol (131252-25-0)

Guidance literature:

Reference yield:

4-ethyl-α,α,α-trifluoroacetophenone (73471-96-2) → 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol (131252-25-0)

Guidance literature:

With sodium tetrahydroborate; In 1,4-dioxane; isopropyl alcohol; at 20 ℃; Rate constant; Thermodynamic data; ΔH (excit.), ΔS (excit.);

upstream raw materials:

4-ethyl-α,α,α-trifluoroacetophenone

trifluoromethan

4-ethylbenzylaldehyde

(trifluoromethylsulfonyl)benzene

Downstream raw materials:

3-Nitro-benzenesulfonic acid 1-(4-ethyl-phenyl)-2,2,2-trifluoro-ethyl ester

Refernces

• 1、 Prakash, G. K. Surya,Hu, Jinbo,Olah, George A.. "Alkoxide- and hydroxide-induced nucleophilic trifluoromethylation using trifluoromethyl sulfone or sulfoxide". . p. 3253 - 3256. Retrieved 2007/10/03.
• 2、 Murata,Sakaguchi,Fujiyama,Mishima,Fujio,Tsuno. "Substituent effects. XX. Highly electron-deficient carbocation solvolyses". . p. 1138 - 1145. Retrieved 2007/10/02.