Technology Process of 2-methyl-3-(methylsulfonyl)-4-(trifluoromethyl)benzoic acid
There total 7 articles about 2-methyl-3-(methylsulfonyl)-4-(trifluoromethyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tungstate (VI) dihydrate; dihydrogen peroxide; acetic acid;
In
water;
at 95 ℃;
for 10h;
Temperature;
Reagent/catalyst;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: nickel dibromide; bis[2-(diphenylphosphino)phenyl] ether; zinc / acetonitrile / 18 h / 10 - 80 °C / Inert atmosphere
2: tri(butyl)tetradecylphosphonium chloride / water / 16.5 h / 50 - 53 °C
3: sodium hydroxide; water / butan-1-ol / 5 h / 125 °C
4: sodium tungstate (VI) dihydrate; acetic acid; dihydrogen peroxide / water / 10 h / 95 °C
With
tri(butyl)tetradecylphosphonium chloride; sodium tungstate (VI) dihydrate; water; dihydrogen peroxide; acetic acid; bis[2-(diphenylphosphino)phenyl] ether; sodium hydroxide; nickel dibromide; zinc;
In
water; acetonitrile; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -50 °C
2: nickel dibromide; bis[2-(diphenylphosphino)phenyl] ether; zinc / acetonitrile / 18 h / 10 - 80 °C / Inert atmosphere
3: tri(butyl)tetradecylphosphonium chloride / water / 16.5 h / 50 - 53 °C
4: sodium hydroxide; water / butan-1-ol / 5 h / 125 °C
5: sodium tungstate (VI) dihydrate; acetic acid; dihydrogen peroxide / water / 10 h / 95 °C
With
tri(butyl)tetradecylphosphonium chloride; sodium tungstate (VI) dihydrate; water; dihydrogen peroxide; acetic acid; bis[2-(diphenylphosphino)phenyl] ether; sodium hydroxide; nickel dibromide; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; water; acetonitrile; butan-1-ol;