C₄₃H₅₂FN₅O₇

Base Information

• Chemical Name: C₄₃H₅₂FN₅O₇
• CAS No.: 1311409-28-5
• Molecular Formula: C₄₃H₅₂FN₅O₇
• Molecular Weight: 769.914
• Mol file: 1311409-28-5.mol

Synonyms:C₄₃H₅₂FN₅O₇

Chemical Property of C₄₃H₅₂FN₅O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₅₂FN₅O₇

There total 31 articles about C₄₃H₅₂FN₅O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H39FN4O4 (1311411-88-7) + (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid (162537-11-3) → C43H52FN5O7 (1311409-28-5)

Guidance literature:

With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

[2-(4-bromo-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (949885-93-2) → C43H52FN5O7 (1311409-28-5)

Guidance literature:

Multi-step reaction with 11 steps

1.1: iodine; magnesium / tetrahydrofuran / 60 - 65 °C / Inert atmosphere

1.2: 3 - 20 °C

1.3: -5 °C

2.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetone / 1 h / 20 °C

3.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 7.33 h / 20 °C

4.1: sodium tri-sec-butylborohydride / tetrahydrofuran / 1.5 h / -65 - -35 °C / Inert atmosphere

4.2: 0 - 10 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 1.5 h / -78 °C

6.1: sodium hydroxide / water; methanol / 3 h / 20 °C

6.2: pH 2 - 3

7.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

8.2: 50 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere

10.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

11.1: HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; ruthenium(III) chloride trihydrate; iodine; sodium tri-sec-butylborohydride; sodium carbonate; potassium hydrogencarbonate; magnesium; triethylamine; HATU; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

C18H24BrNO3 (1311410-93-1) → C43H52FN5O7 (1311409-28-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium periodate; ruthenium(III) chloride trihydrate / water; acetone / 1 h / 20 °C

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 7.33 h / 20 °C

3.1: sodium tri-sec-butylborohydride / tetrahydrofuran / 1.5 h / -65 - -35 °C / Inert atmosphere

3.2: 0 - 10 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: 1.5 h / -78 °C

5.1: sodium hydroxide / water; methanol / 3 h / 20 °C

5.2: pH 2 - 3

6.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

7.2: 50 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 110 °C / Inert atmosphere

9.1: hydrogenchloride / isopropyl alcohol / 0.5 h / 20 °C

10.1: HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium periodate; ruthenium(III) chloride trihydrate; sodium tri-sec-butylborohydride; sodium carbonate; potassium hydrogencarbonate; triethylamine; HATU; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

upstream raw materials:

o-fluorobenzyl bromide

2-monochlorophenol

4-bromophenethanol

8-chloro-2,3-dihydro-4H-1-benzopyran-4-one

Refernces

• 1、 -. "5-AMINO- 4-HYDROXYPENTOYL AMIDES". . . Retrieved 2011/06/26.